揭开阻塞性睡眠呼吸暂停和轻度认知障碍之间的双向联系:系统性审查和元分析
Yan Ren1, Shanping Chen1, Hongping Wang2
1Geriatric Diseases Institute of Chengdu, Department of Gerontology and Geriatrics, Chengdu Fifth People's Hospital (The Second Clinical Medical College, Affiliated Fifth People's Hospital of Chengdu University of Traditional Chinese Medicine), Chengdu, 611137, China.
阻塞性睡眠呼吸暂停 (OSA) 与较高的轻度认知障碍 (MCI) 患病率有关. 早期的OSA查可能有助于减少受影响个体的认知衰退.
科学领域:
- 神经学 神经学
- 睡眠医学 睡眠医学
- 老年学是指老年学的学科.
背景情况:
- 轻度认知障碍 (MCI) 是正常认知衰老和痴呆症之间的过渡阶段.
- 阻塞性睡眠呼吸暂停 (OSA) 越来越被认为是导致MCI发展的潜在风险因素.
- 了解OSA和MCI之间的相互作用对于有效的早期干预策略至关重要.
研究的目的:
- 系统地审查和量化被诊断为OSA的个体中MCI的患病率.
- 调查患有MCI的个体中OSA的患病率.
- 探索OSA和MCI之间的双向关系和关联.
主要方法:
- 在主要数据库 (Cochrane Library,PubMed,Ovid,Embase,Web of Science) 进行了全面的文献搜索,截至2024年5月30日.
- 包括的研究报告了MCI和/或OSA的流行数据.
- 统计分析,包括聚合流行率和几率比率 (OR) 计算,使用R中的随机效应模型进行,并进行子组和灵敏度分析以解决异质性.
主要成果:
- 分析包括22项研究,涉及73733名参与者.
- 同时发生的OSA和MCI的综合患病率为20% (95%CI:10%-30%).
- 在OSA患者中MCI的患病率为39% (95%CI:24%-53%),MCI患者中的OSA患病率为39% (95%CI:23%-55%).
- 总体概率比为1.65 (95% CI: 1.39-1.96),表明OSA和MCI之间存在显著的关联.
结论:
- 这一元分析证实了同时发生的OSA和MCI的高患病率,建立了显著的关联.
- 这些发现强调了对OSA的早期查和及时干预的关键需求.
- 积极管理OSA可能在减轻认知能力下降和防止发展为痴呆症方面发挥重要作用.
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