基于一般人群的肺功能在一生中的发展轨迹:加速队列研究
Judith Garcia-Aymerich1, Martí de Las Heras1, Anne-Elie Carsin1
1ISGlobal, Barcelona, Spain; Universitat Pompeu Fabra, Barcelona, Spain; CIBER Epidemiología y Salud Pública, Madrid, Spain.
The Lancet. Respiratory medicine
|May 18, 2025
概括
这项研究揭示了儿童和青春期肺功能 (FEV1和FVC) 在两个阶段增加,在成年早期达到顶峰. 肺功能比以前想象的更早地下降,FEV1/FVC比率在一生中下降.
科学领域:
- 肺部病理学 肺部病理学
- 流行病学 流行病学
- 生命历程研究 生命历程研究
背景情况:
- 目前对肺功能增长和衰退的理解受到碎片化和潜在偏见的数据的限制.
- 建立基于一般人口的生命周期轨迹对于准确的健康评估至关重要.
- 识别肺功能中断点和高原对于理解呼吸系统健康动态至关重要.
研究的目的:
- 在经验上推导出基于一般人口的肺功能生命周期轨迹.
- 为了确定肺功能在整个生命周期中的关键断点和高原.
- 研究喘和吸烟对肺功能轨迹的影响.
主要方法:
- 汇集了来自欧洲和澳大利亚八个普通人口队列研究的数据,以创建加速队列.
- 利用交叉分类的三级线性混合模型来推导性别特定的肺功能轨迹 (FEV1,FVC,FEV1/FVC比率) 从4-80岁.
- 采用贝叶斯时间序列分解来确定断点和平原,并对喘和吸烟状况进行分层分析.
主要成果:
- FEV1和FVC轨迹显示出两个不同的增长阶段,在衰退之前在成年早期 (大约20-23岁) 达到顶峰.
- 肺功能下降的时间比以前报告的更早,在峰值后没有观察到平原.
- FEV1/FVC比率在一生中持续下降. 持续性喘和吸烟与不良的肺功能结果有关.
结论:
- 肺功能 (FEV1,FVC) 遵循双相生长模式,在成年早期达到峰值,然后下降,下降的开始比以前理解的要早.
- 在整个生命过程中,FEV1/FVC比率持续下降.
- 这些发现为评估和监测整个生命的呼吸系统健康建立了重要框架,突出了喘和吸烟的影响.
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