在初级整部关节整形术后,黑素能改善睡眠吗? 一个随机的,双盲的,安慰剂控制的试验
Muhammad A Haider1, Kyle W Lawrence1, Thomas Christensen1
1Department of Orthopedic Surgery, NYU Langone Health, New York, New York.
The Journal of arthroplasty
|May 18, 2025
概括
关节整体整形手术 (THA) 后,黑素补充剂可能不会改善整体睡眠质量,但它可以在术后早期增加睡眠时间. 这项研究表明,黑激素对患有急性睡眠障碍的THA患者是安全的.
科学领域:
- 整形外科手术 整形外科手术
- 睡眠医学 睡眠医学
- 药理学 药理学是指药理学的学科.
背景情况:
- 关节整形术 (THA) 后睡眠障碍很常见,可能会阻碍患者的满意度和恢复.
- 没有确定的术后指导方针来管理THA后的睡眠问题.
- 这项研究研究了黑激素在改善THA后睡眠的有效性.
研究的目的:
- 评估黑激素对接受THA的患者睡眠质量和数量的影响.
- 为了评估黑激素对疼痛,睡眠时间和夜间觉醒的影响.
- 为了确定黑激素是否能改善患者报告的睡眠障碍得分.
主要方法:
- 一项随机对照试验,涉及139名接受选择性THA治疗的患者.
- 参与者每晚接受5毫克的黑激素或安慰剂,持续14天.
- 睡眠日记 (疼痛,睡眠时间,觉醒),爱普沃思睡眠分数 (ESS) 和PROMIS-SD表格用于评估.
主要成果:
- 术后的ESS得分在黑激素和安慰剂组之间是可比的 (P = 0.35).
- 黑色素使用者在术后第二天的睡眠时间显著增加 (P = 0.017).
- 氨酸组报告了术后PROMIS-SD得分明显较低 (P = 0.040),表明睡眠障碍减少.
结论:
- 根据ESS的测量,黑素并没有显著改善整体术后睡眠质量.
- 黑色素可能会在THA后的最初1-3天提高睡眠时间,之后的好处会减少.
- 对于患有早期术后睡眠障碍的THA患者来说,黑色素是一种安全的选择.
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