在分娩后立即表达内分泌和代谢参数的牛-小牛关系
A L Freihofer1, R M Bruckmaier1, J J Gross1
1Veterinary Physiology, Vetsuisse Faculty, University of Bern, 3012 Bern, Switzerland.
Journal of dairy science
|May 18, 2025
概括
孕产妇的新陈代谢状况在第一次养前影响小牛的健康,而母乳则调解后来的关联. 这项研究探讨了乳牛及其新生儿在生命早期的关键联系.
科学领域:
- 兽医医学 兽医医学 兽医医学
- 动物科学动物科学
- 新生儿生理学 新生儿生理学
背景情况:
- 产妇健康和分娩事件显著影响新生儿内分泌和代谢通路.
- 婴儿早期的营养,特别是乳酪,对于新生儿的发育至关重要.
- 了解奶牛和新生儿的代谢相互作用对于小牛的健康和生产力至关重要.
研究的目的:
- 调查母乳和新生儿代谢和内分泌参数在奶牛及其小牛之间的关联.
- 为了确定母体代谢状态对新生儿发育在领奶粉摄入之前和之后的影响.
- 确定与新生儿脂质,葡萄糖和蛋白质代谢相关的特定母性因素.
主要方法:
- 血液样本从46只健康的母牛及其小牛中收集,分娩后的不同时间间隔 (4,12,24小时).
- 分析主要的代谢标记物,包括葡萄糖,非化脂肪酸 (NEFA),胰岛素,IGF-1,益生菌 (PRL),脂 (PL),总胆固醇 (TC),LDL-C,HDL-C和IgG.
- 皮尔森相关系数计算用于评估母亲和新生儿参数之间的关系.
主要成果:
- 产后4小时的孕产妇葡萄糖与新生儿葡萄糖和NEFA正相关.
- 产后4小时内,母亲的NEFA与新生儿脂肪代谢 (PL,HDL-C) 和IgG负相关.
- 在母体葡萄糖和新生儿葡萄糖之间观察到显著的正相关性 (12 & 24h p.p. ),以及母体NEFA和新生儿脂质参数 (24小时PPP). ) 的情况.
- 产后母乳素 (PRL) 与新生儿脂质代谢参数 (NEFA,PL,TC,LDL-C,HDL-C) 在产后12小时和24小时之间显示出强烈的正相关性.
结论:
- 新生儿的新陈代谢状态在一定程度上受母体新陈代谢的影响,在第一次母乳食之前.
- 牛奶和小牛的新陈代谢之间的乳母乳后关联可能是由乳母乳成分介导的.
- 这些发现凸显了母亲代谢健康对新生儿成功适应的重要性.
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