相关实验视频

Updated: Apr 30, 2026

Accurate Follicle Enumeration in Adult Mouse Ovaries

Accurate Follicle Enumeration in Adult Mouse Ovaries

Published on: October 16, 2020

一项病例对照研究,研究了毛囊液中微量元素暴露与早产卵巢衰竭之间的联系

Xiaowen Liu¹, Zewei Yu¹, Yangying Xu¹

¹Center for Reproductive Medicine, Women and Children's Hospital, Qingdao University, Qingdao, China; Branch of Shandong Provincial Clinical Research Center for Reproductive Health, Qingdao, China; College of Medicine, Qingdao University, Qingdao, China.

Reproductive toxicology (Elmsford, N.Y.)

|May 18, 2025

概括

毛囊液中的微量元素对女性生育能力产生影响. 铜和等特定元素可以防止过早的卵巢衰竭 (POI),而和等其他元素则会增加风险.

科学领域:

环境健康环境健康
生殖生物学生殖生物学
毒理学毒理学毒理学

背景情况:

过早卵巢衰竭 (POI) 影响3.5%的40岁以下女性,超过50%的病例的病因不明.
环境因素,包括微量元素,与降低生育率和不良健康结果有关.
关于毛囊液中的微量元素与POI之间的具体联系的研究有限.

研究的目的:

研究毛囊液中的25种微量元素与早产卵巢缺陷 (POI) 风险之间的关联.
探索微量元素度和卵巢储备标记物之间的关系,特别是抗米勒尔激素 (AMH) 和基底FSH (bFSH).

主要方法:

从367名女性患者 (POI组和对照组) 的毛囊液中使用ICP-MS.分析了25种微量元素.
贝叶斯核心机器回归和受限制的立方线被用来分析组合和单个微量元素效应.
物流回归和后置纳入概率模型评估了与POI的关联,并确定了关键因素.

主要成果:

在POI和对照组之间,在24个检测到的微量元素中,在23个中发现了显著的差异.
在Cu,I,Se和Zn与AMH之间观察到正相关性;与Ca,Co,Li之间观察到负相关性.
高水平的Cu,I,Pb,Se和Zn与POI的可能性较低有关,而Ba,Ca,Cd,Li,Mn和Ni与POI的可能性增加有关.

结论:

这项研究确定了毛囊液中的特定微量元素与POI风险之间的联系.
研究结果强调了环境污染物在女性生殖健康和卵巢功能中的关键作用.
提供了监测女性生育能力和了解环境因素对生殖健康的影响的基础.

关键词:

环境污染物环境污染物女性不孕症妇女不孕症过早的卵巢衰竭是早产的微量元素的微量元素是什么毛囊液体毛囊液体毛囊液体

更多相关视频

Exploring X Chromosomal Aberrations in Ovarian Cells by Using Fluorescence In Situ Hybridization

Exploring X Chromosomal Aberrations in Ovarian Cells by Using Fluorescence In Situ Hybridization

Published on: April 7, 2023

Author Spotlight: Investigating the Relationship Between FSH and Pathophysiological Changes in Perimenopausal Women - Insights from a Mouse Model

Author Spotlight: Investigating the Relationship Between FSH and Pathophysiological Changes in Perimenopausal Women - Insights from a Mouse Model

Published on: August 11, 2023

相关概念视频

Oogenesis

Oogenesis

In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...

Folliculogenesis

Folliculogenesis

Folliculogenesis is the development of ovarian follicles, the specialized structures within the ovarian cortex where oogenesis, or egg development, occurs. This process is essential for female reproductive health and begins during fetal development when primordial follicles are formed. Each primordial follicle comprises a primary oocyte in the center, surrounded by a single layer of squamous pre-granulosa cells. These follicles remain dormant in late prophase I of meiosis until triggered by...

Hormonal Control of the Ovarian Cycle

Hormonal Control of the Ovarian Cycle

The ovarian cycle is meticulously regulated by the hypothalamic-pituitary-gonadal axis. This cycle orchestrates the release of a mature oocyte, essential for reproduction.
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle. At puberty, GnRH secretion increases in both frequency and...