脱氧尼瓦伦醇和男性生殖毒性:揭开隐藏的风险
Ana Laura Paulino Leite Gomes1, Glaura Scantamburlo Alves Fernandes2, Ana Paula Frederico Rodrigues Loureiro Bracarense1
1Laboratory of Animal Pathology, Universidade Estadual de Londrina, Rodovia Celso Garcia Cid, km 380, 86057-970, Londrina, Paraná, Brazil.
Toxicology
|May 18, 2025
概括
脱氧尼瓦伦醇 (DON) 暴露会通过影响精子质量和数量,对男性生殖健康产生负面影响. 父母DON暴露也会导致后代的不良发育,这证实了它的毒性作用.
科学领域:
- 毒理学 毒理学 毒理学
- 生殖生物学 生殖生物学
- 环境健康 环境健康
背景情况:
- 脱氧尼瓦伦醇 (DON) 是一种广泛存在的真菌毒素,具有已知的胃肠道和免疫作用.
- 新出现的证据表明,DON也会损害男性生殖功能.
- 了解DON的生殖毒性对公共健康至关重要.
研究的目的:
- 审查目前关于DON对男性生殖器官的影响的证据.
- 强调DON对荷尔蒙平衡,生殖表皮和血液丸屏障的影响.
- 探索DON对辅助生殖器官和后代发育的影响.
主要方法:
- 关于研究DON对男性生殖的影响的综合文献综述.
- 分析包括氧化应激,炎症和亡在内的机制.
- 对父母DON暴露和后续后代结果的研究的评估.
主要成果:
- 会扰乱荷尔蒙调节,损害生殖表皮,并损害血屏障.
- 氧化应激,炎症和亡是调解DON毒性的关键机制.
- 观察到精子质量和数量下降,腹膜,前列腺和精液囊功能受损.
- 父母的DON暴露会对后代在不同阶段的发育产生不利影响.
结论:
- 脱氧尼瓦伦醇对男性生殖健康构成重大威胁.
- 由DON引起的变化导致生育能力受损和潜在的跨代效应.
- 需要进一步的研究来充分阐明DON的生殖毒理学及其影响.
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