尿路杀虫剂代谢物和与学龄儿童甲状腺体积的关联
Fuhai Zhong1, Conghui Xu2, Fenfang Deng2
1Guangzhou Center for Disease Control and Prevention, Guangzhou, 510440, China; School of Public Health, Sun Yat-sen University, Guangzhou, 510080, China.
儿童接触农药可能会影响甲状腺体量,可能是通过水平. 监测甲状腺健康对于早期发现疾病至关重要.
科学领域:
- 环境健康 环境健康
- 儿科内分泌学 儿科内分泌学
- 毒理学 毒理学 毒理学
背景情况:
- 儿童甲状腺体积监测为评估甲状腺疾病提供了一种非侵入性方法.
- 农药暴露是一个越来越令人担忧的问题,可能会对儿童健康产生影响.
- 了解影响儿童甲状腺健康的环境因素对于公众健康至关重要.
研究的目的:
- 研究8-11岁儿童尿液农药代谢物,尿液和甲状腺体量之间的关联.
- 评估农药代谢物的空间分布和相关的健康风险.
- 探索尿在农药暴露和甲状腺体量之间关系中的调解作用.
主要方法:
- 在中国广州地区进行的横截面研究,涉及8至11岁儿童.
- 测量尿液中的农药代谢物 (有机酸,甲酸,氧碳酸) 和尿液中的.
- 统计分析包括多变量线性回归,趋势测试,受限立方线和贝叶斯核机器回归.
主要成果:
- 甲状腺体积与年龄和身体表面积正相关,与尿负相关.
- 两个甲状腺代谢物 (cis-DCCA和trans-DCCA) 显示出与甲状腺体积的负相关性.
- 杀虫剂代谢物与甲状腺体积的关联是由尿液中介导的.
结论:
- 农药暴露可能会影响儿童的甲状腺体量,尿液中的起着调解作用.
- 在环境暴露的背景下,状态是评估甲状腺健康的重要因素.
- 研究结果强调,需要采用综合方法来监测环境健康和儿科甲状腺功能.
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