空气污染和夜间人工光对糖尿病风险的协同作用:一项前性队列研究
Desong Wen1, Fei Lin1, Chaowei Zhang1
1The First Affiliated Hospital of Xinxiang Medical University. Henan Engineering Technology Research Center of Environmental Meteorological Medicine, Xinxiang, Henan, 453001, China.
Environmental pollution (Barking, Essex : 1987)
|May 18, 2025
概括
空气污染和夜间的人工光 (ALAN) 会增加糖尿病的风险. 这项研究发现了PM2.5和ALAN等污染物之间的协同作用,特别是在老年人和未婚成年人中,突出了预防糖尿病的环境因素.
科学领域:
- 环境健康 环境健康
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 以前的研究表明,空气污染物,夜间室外人工光 (ALAN) 和糖尿病风险之间存在联系.
- 然而,这些环境因素对糖尿病发病率的相互作用影响需要进一步验证.
研究的目的:
- 调查特定空气污染物和户外ALAN暴露与糖尿病发病率的关联.
- 检查空气污染物和户外ALAN对糖尿病风险的相互作用影响.
- 识别这些关联中的敏感人群和区域差异.
主要方法:
- 利用了来自两个大型中国队列 (CHARLS和CFPS) 的数据,其中28903名参与者被跟踪了3年 (2013-2018).
- 使用Cox比例危险回归模型来评估关联和相互作用.
- 根据年龄,婚姻状况和地区进行了分层分析.
主要成果:
- 在PM1和PM2.5度和糖尿病风险增加之间发现了显著的线性关联 (HR分别为1.065和1.036每10μg/m3增加).
- 户外ALAN暴露与糖尿病风险有非线性关联 (HR为每SD增加1.004).
- 观察到对PM1,PM2.5,PM10,SO2和室外ALAN的同时暴露有显著的协同效应. 在65岁以上的个人,未婚人口,北方居民 (污染物) 和南方居民 (ALAN) 中发现风险更高.
结论:
- 这项研究首次证实了环境污染物和户外ALAN暴露对糖尿病风险的显著协同作用.
- 强调空气和光污染在预防和控制糖尿病中的关键作用.
- 为制定未来的公共卫生政策提供理论基础,以解决环境暴露和糖尿病问题.
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