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在神经退行性疾病中视网膜成像生物标志物的系统审查和网络元分析:与大脑变化的相关性

Farzaneh Nikparast¹, Zohreh Ganji¹, Hoda Zare²

¹Medical Physics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; Student research committee, Mashhad University of medical sciences, Mashhad, Iran.

Photodiagnosis and photodynamic therapy

|May 18, 2025

概括

视网膜变薄,特别是在围神经纤维层和内黄斑区域,可能表明早期的神经退行性疾病 (ND),如轻度认知障碍 (MCI). 晚期阿尔茨海默病 (AD) 呈现出进一步的视网膜和大脑缩.

科学领域:

眼科医生眼科眼科
神经学神经学
生物标志物生物标志物

背景情况:

视网膜和大脑有着共同的发育起源和神经特征.
神经退行性疾病 (NDs) 在两个器官中引发共同的结构和生理变化.
识别共享的生物标志物对于早期的ND检测至关重要.

研究的目的:

进行系统和网络元分析 (NMA) 以识别神经退行性疾病中的视网膜-大脑生物标志物.
为了比较阿尔茨海默病 (AD) 和轻度认知障碍 (MCI) 与对照的视网膜层厚度变化.

主要方法:

进行了随机效应网络元分析 (NMA).
分析了来自225名AD患者,97名MCI患者和345名认知正常 (CN) 个体 (2016-2023) 的视网膜层厚度数据.
大脑成像发现被评估用于比较分析.

主要成果:

与对照人群相比,轻度认知障碍 (MCI) 在下部和上部外皮皮质视网膜神经纤维层 (pRNFL) 和内黄斑厚度显著稀薄.
与MCI相比,阿尔茨海默氏病 (AD) 在特定的pRNFL区域和外侧黄斑厚度进一步变薄.
在大多数地区,在AD和认知正常 (CN) 个体之间没有观察到显著的视网膜差异.

结论:

上部和下部PRNFL和内黄斑变薄可能作为MCI的早期生物标志物.
在阿尔茨海默氏症中,视网膜层变薄与海马,内腔皮层和叶缩相关.
黄斑体积 (EZ-RPE) 显示了与AD的总大脑体积的相关性.

关键词:

这就是为什么MRI是MRI.磁共振成像技术磁共振成像技术神经退行性疾病的神经退行性疾病其他国家和地区.光学连贯性断层扫描仪视网膜层是一种视网膜层.

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