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显微型大肠炎的单细胞转录学特征

Stefan Halvorsen1, Molly Thomas2,3,4,5,6, Mari Mino-Kenudson5,7

  • 1Center for Computational and Integrative Biology, Massachusetts General Hospital (MGH), Boston, MA, USA.

Nature communications
|May 18, 2025
PubMed
概括

微观性结肠炎涉及结肠内特定T细胞的增加. 针对这些T细胞子集可能为这种慢性炎症性肠病提供新的治疗方法.

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The large intestine hosts the most densely populated microbial ecosystem in the human body. This complex community primarily consists of anaerobic bacteria, with Bacillota (formerly Firmicutes) and Bacteroidota (formerly Bacteroidetes) as the predominant groups. The distribution of these microbes varies along different sections of the large intestine, influenced by local environmental factors such as oxygen availability and nutrient composition.The cecum, located at the beginning of the large...