在母乳强化后的血氨基酸和与早产婴儿生长的关联
Martin Bo Rasmussen1, Kristine Holgersen1,2, Tik Muk1
1Comparative Pediatrics, Section for Biomedicine, Department of Veterinary and Animal Sciences, University of Copenhagen, Frederiksberg, Denmark.
Pediatric research
|May 18, 2025
概括
人类牛奶的牛乳强化增加了非常早产婴儿的血氨基酸. 这些变化与头部增长和IGF-1相关,但对整体增长结果的影响有限.
科学领域:
- 新生儿营养新生儿营养
- 儿科胃肠病学 儿科胃肠病学
- 生物化学 生化学
背景情况:
- 血氨基酸 (AA) 含量及其对接受强化母乳的非常早产婴儿 (VPI) 的生长的影响尚不清楚.
- 不同类型的强化对AA度和随后的生长因子,如胰岛素类生长因子1 (IGF-1) 的影响尚不清楚.
研究的目的:
- 为了研究用牛乳 (BC) 与常规强化剂 (CF) 对人乳强化如何影响VPI中的血AA度.
- 确定血AA度变化与生长参数 (体重,长度,头周) 和VPI中的IGF-1水平之间的关联.
主要方法:
- 一项涉及225个VPI的研究,其中母乳被BC或CF强化.
- 血样本在基线 (~1周大) 和强化后1周和2周收集.
- 增长Z-分数和IGF-1度被监测到35周的月经后年龄.
主要成果:
- 与CF相比,BC强化导致12AA度增加和氨酸减少.
- 血AA的增加与头周长的增长和IGF-1水平呈正相关.
- AA变化与妊娠年龄和出生体重相反相关,但血蛋白质组没有受到影响.
结论:
- 牛乳粉强化可显著改变VPI中的血AA概况,增加许多AA度.
- 强化诱导的AA变化与头部生长和IGF-1有关,但对体重或长度增长的预测价值有限.
- 虽然强化影响AA水平,但这些变化似乎对VPI的早期生长和健康结果具有最小的临床影响.
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