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在帕金森病中嗅觉功能的下降:一项为期十年的纵向研究
Dareia S Roos1,2, Martin Klein3, Richard L Doty4
1Department of Neurology, Amsterdam UMC location Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Journal of Parkinson's disease
|May 19, 2025
概括
嗅觉功能障碍随着时间的推移在帕金森病 (PD) 患者中显著恶化. 在PD患者中,嗅觉功能的这种下降超过了与年龄相关的变化,并可能作为疾病进展的标志物.
科学领域:
- 神经学 神经学
- 神经科学是一个神经科学.
- 老年学是一门学科.
背景情况:
- 嗅觉功能障碍是帕金森病 (PD) 的常见早期症状,影响高达90%的患者.
- 在PD的整个过程中,嗅觉衰退的进展在很大程度上仍然没有特征.
研究的目的:
- 调查PD患者的嗅觉功能下降是否加速超过预期的与年龄相关的变化.
- 评估PD患者长期随访期间的嗅觉功能变化.
主要方法:
- 利用宾夕法尼亚大学的气味识别测试 (UPSIT) 来评估90名PD患者的嗅觉功能,在基线和平均10年后.
- 采用迷你心理状态检查 (MMSE) 来识别和解释潜在的混性认知缺陷.
主要成果:
- 在基线时,UPSIT的平均得分为22. 在10年内,81.1%的PD患者经历了嗅觉功能的下降.
- UPSIT评分的平均下降为6分,明显超过了与年龄相关的下降预期.
- 即使排除了认知障碍患者 (MMSE <24),嗅觉功能仍然下降了近7个点.
结论:
- 帕金森病的嗅觉功能以比单独归因于衰老或认知衰退的速度更快的速度恶化.
- 嗅觉功能是监测帕金森病进展的有希望的非侵入性生物标志物.
- 这些发现支持将嗅觉测试纳入PD管理的多式模式表型化策略.
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