患产后精神病的家族风险
Adrianna P Kępińska1, Thalia K Robakis1, Keith Humphreys1
1Seaver Autism Center for Research and Treatment (Kępińska, Mahjani), Department of Psychiatry (Kępińska, Robakis, Kahn, Bergink, Mahjani), Department of Genetics and Genomic Sciences (Kępińska, Mahjani), Mindich Child Health and Development Institute (Mahjani), and Department of Artificial Intelligence and Human Health (Mahjani), Icahn School of Medicine at Mount Sinai, New York; Department of Medical Epidemiology and Biostatistics (Humphreys, Mahjani) and Department of Molecular Medicine and Surgery (Mahjani), Karolinska Institutet, Stockholm; Department of Clinical Research, Research Unit Children and Adolescent Psychiatry, University of Southern Denmark, Odense (Liu, Munk-Olsen); Department of Psychiatry, Erasmus Medical Center, Rotterdam, the Netherlands (Bergink).
在完整的兄弟姐妹中,产后精神病的家族风险高于表兄弟姐妹,这表明遗传和环境因素. 然而,即使有受影响的兄弟姐妹,整体风险仍然很低.
科学领域:
- 精神病学是一个精神病学.
- 遗传学 是一个遗传学.
- 流行病学 流行病学
背景情况:
- 产后精神病 (PP) 是一种具有重大风险的严重精神疾病.
- 遗传因素与PP有关,但家族风险的程度需要进一步调查.
研究的目的:
- 为了比较不同家庭关系中产后精神病的相对复发风险.
- 为了确定家族风险是否因遗传亲属关系而有所不同,特别是比较女性完全兄弟姐妹和表妹.
主要方法:
- 一项使用瑞典全国性登记册的队列研究.
- 涉及1648,759名妇女,在分娩后3个月内确定了2514例产后精神病.
- 估计女性全兄弟姐妹和表妹的相对复发风险.
主要成果:
- 完整的兄弟姐妹显示,产后精神病的相对复发风险显著增加 (10.69).
- 表亲有较高但不具有统计学意义的相对复发风险 (1.78).
- 患有受影响兄弟姐妹的妇女的绝对风险很低 (1.60%).
结论:
- 完全兄弟姐妹的风险增加表明了结合的遗传和共同的环境影响.
- 在表兄弟中缺乏显著的发现限制了区分这些因素.
- 需要进一步的研究来阐明遗传学和环境在分娩后精神病中的相互作用.
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