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一次tDCS刺激会可以调节与抑郁症患者焦虑相关的EEG微态

Keiichiro Nishida^1,2, Shota Minami², Tomonari Yamane¹

¹Department of Neuropsychiatry, Osaka Medical and Pharmaceutical University, Osaka, Japan.

Brain and behavior

|May 19, 2025

概括

经直流刺激 (tDCS) 改变了抑郁症患者的脑电图 (EEG) 微态 D 持续时间. 微态D的变化可以作为焦虑的客观生物标志物,特别是在分析过渡时,而不仅仅是持续时间.

科学领域:

神经科学是一个神经科学.
精神病学是一个精神病学.
计算神经科学是一种神经科学.

背景情况:

脑电图 (EEG) 微态分析检查精神疾病中的神经动态.
超直流刺激 (tDCS) 是一种非侵入性脑刺激技术.
抑郁症是一种复杂的精神疾病,具有神经活动模式的改变.

研究的目的:

在抑郁症患者中研究tDCS对EEG微态图D和C的影响.
针对特定的大脑区域:背中前额叶皮层 (DMPFC) 和左侧前额叶皮层 (DLPFC).
探索微观状态参数作为精神疾病的潜在生物标志物.

主要方法:

19名抑郁症患者的开放标签,受试者之间的交叉试验.
给DMPFC或左边的DLPFC注入1mA的阳极tDCS.
在tDCS之前和之后记录了静止状态EEG,分析了五个微状态类.

主要成果:

在两个刺激组中,tDCS后微状态类D持续时间显著增加.
在微态C类持续时间中没有观察到显著的变化.
从微观状态D到C的过渡与离开DLPFC刺激后的焦虑得分降低相关.

结论:

微态地图D与执行功能和精神疾病有关.
微态地图C可能与突出网络和思维漫游有关.
脑电图微态D和C对tDCS有反应,这表明客观焦虑评估的潜力;过渡分析可以改善情绪状态跟踪.

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