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孕期影响胎儿心脏病风险的孕妇暴露因素:一个病例控制研究

Jieru Lu^1,2,3, Zhuoyan Li¹, Yu Wang^1,2

¹Department of Pediatric Cardiology, School of Medicine, Xinhua Hospital, Shanghai Jiao Tong University, Shanghai, China.

Cardiology in the young

|May 19, 2025

概括

室内空气质量和住宅特征等环境因素显著影响先天性心脏病 (CHD) 风险. 保护性饮食习惯和叶酸摄入量可以减轻后代的这些风险.

科学领域:

环境健康环境健康
儿童心脏病学儿童心脏病学
生殖健康生殖健康

背景情况:

先天性心脏缺陷 (CHD) 是一个重要的全球健康问题.
了解环境风险因素对心血管疾病患病率的影响对于制定有针对性的预防策略至关重要.

研究的目的:

评估环境风险因素与子女先天性心脏缺陷 (CHD) 患病率之间的关联.
研究饮食因素和营养素的潜在保护作用.

主要方法:

一项基于医院的病例控制研究在中国东部进行了31例心血管疾病病例和72例对照病例.
收集了有关住宅特征,室内空气质量,饮食和母亲病史的数据.
使用单变量和多变量逻辑回归模型来估计风险比率并分析介导效应.

主要成果:

心血管疾病风险增加与住宅特征 (水泥地板,味) 和室内空气污染物 (总挥发性有机化合物,) 有关.
叶酸摄入量表现出掩盖效应,减少挥发性有机化合物和甲对心血管疾病发病率的影响.
饮食因素,如牛奶,海鱼和小麦摄入量被确定为预防心脏病的保护因素.
母亲生殖史,睡眠质量和工作时间也影响了心脏病发病率.

结论:

饮食习惯,营养摄入量,母亲的心理状态和住宅空气质量与胎儿心血管疾病有关.
室内挥发性有机化合物水平与心血管疾病风险有显著的相关性.
叶酸可以起到保护作用,减轻空气污染物对胎儿发育的不良影响.

关键词:

的 CHDs 的使用.环境因素环境因素母亲暴露的母亲暴露.总挥发性有机化合物总量

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