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卡路里限制对年轻ApoE/LDLr小鼠动脉样硬化的负面影响
Renata B Kostogrys1,2, Magdalena Franczyk-Żarów3, Artur Gurgul4
1Department of Human Nutrition and Dietetics, Faculty of Food Technology, University of Agriculture in Krakow, Balicka 122, 30-149 Kraków, Poland, rkostogrys@ar.krakow.pl.
概括
卡路里限制 (CR) 在年轻小鼠中恶化了动脉样硬化,尽管体重和甘油三降低了. 相比之下,成年小鼠在动脉样硬化标志物中没有显著变化. 这突显了CR对心血管健康的年龄相关影响.
科学领域:
- 心血管研究研究心血管研究
- 代谢性疾病 代谢性疾病
- 营养科学 营养科学
背景情况:
- 热量限制 (CR) 是一种已知的治疗肥胖相关心血管疾病 (CVD) 的干预措施.
- 慢性硬化对心血管疾病发展的影响可能随年龄而异.
- 脂蛋白E/低密度脂蛋白受体淘汰 (ApoE/LDLr-/-) 小鼠是研究动脉样硬化的模型.
研究的目的:
- 研究CR对动脉样硬化发展的年龄相关影响.
- 评估CR对年轻与成年ApoE/LDLr-/-小鼠的脂质特征,基因表达和微生物群的影响.
主要方法:
- 年轻 (8周大) 和成年 (20周大) ApoE/LDLr/-小鼠分别接受了CR (30%少饮食) 或控制饮食,分别为8周和5周.
- 控制组包括自由选择 (AL) 的小鼠和单独安置的自由选择 (sAL) 的小鼠.
- 分析了体重,脂质水平 (TCh,LDL,TAG),动脉样硬化,FMO3基因表达和肠道微生物群组成.
主要成果:
- 在年轻小鼠和成年小鼠中,CR显著降低了体重和TAG水平.
- 年轻的CR小鼠表现出TCh和LDL水平的增加,并发展出恶化的动脉样硬化.
- 成年CR小鼠与对照小鼠相比,在动脉样硬化方面没有显著差异,尽管在年轻CR小鼠中改变了微生物群和FMO3上调.
结论:
- 热量限制在年轻的ApoE/LDLr-/-小鼠中加剧动脉样硬化.
- 年龄是影响卡路里限制对心血管的影响的关键因素.
- CR改变了肠道微生物群和FMO3表达,特别是在年轻小鼠中,可能导致动脉样硬化.
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