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生物后果和评估方法固定正牙器件对口腔上皮细胞的分析:系统性审查

Francesco Paolo Modugno¹, Elisabetta Kuhn^2,3, Chiara Luisa Bianchi²

¹Section of Dentistry, Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy.

Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology

|May 19, 2025

概括

固定式正牙器械 (OA) 可以导致由于机械创伤和金属离子而导致口腔组织的可逆细胞和遗传变化. 这些变化往往会回归,看起来没有进展到发育不良.

科学领域:

口腔生物学口腔生物学
生物材料科学是生物材料的科学.
细胞遗传学细胞遗传学

背景情况:

固定式正牙器件 (OA) 将口腔粘膜置于机械应力和金属离子释放的条件下.
了解OA的细胞和遗传影响对于患者的安全至关重要.

研究的目的:

审查固定牙科治疗的细胞学和遗传变化.
评估这些变化的临床影响和评估方法.

主要方法:

在PubMed,Scopus和Web of Science中进行全面的文献搜索.
遵循PRISMA指南和PICO模型;评估偏差风险和研究质量.

主要成果:

包括19项研究;发现表明金属含量增加,细胞学变化和基因毒性作用.
器械的组成和治疗持续时间会影响生物学结果.
观察到核变化的回归趋势;没有发现异位变化.

结论:

酸盐诱导可逆的细胞变化,而不是进展到发育不良.
未来的研究需要使用标准化方法进行纵向研究,以确认可逆性和探索更安全的材料.

关键词:

细胞科学细胞学牙科牙科牙科牙科固定式的正牙器具固定式的正牙器具金属的金属的金属.在口腔的粘膜.

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