相关实验视频
Updated: May 20, 2025
08:40
Chronic Salmonella Infection Induced Intestinal Fibrosis
Published on: September 22, 2019
6.9K
在患有炎症性肠道疾病的儿童体质缺陷的临床风险因素
Erin Alexander1,2, Ronen Stein2, Sharmistha Rudra3
1Division of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatric and Adolescent Medicine, Mayo Clinic Children's Center, Rochester, Minnesota, USA.
Journal of pediatric gastroenterology and nutrition
|May 19, 2025
概括
身体组成缺陷,特别是低瘦质量,在儿科炎症性肠病 (IBD) 中很常见,通常被正常的BMI掩盖. 早期发现这些缺陷对于改善IBD儿童的临床结果至关重要.
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 营养科学 营养科学
- 身体组成分析分析.
背景情况:
- 患有炎症性肠病 (IBD) 的儿童经常表现出低体重指数 (BMI).
- 体重指数没有区分脂肪和瘦肉体质量.
- 身体组成缺陷可能与儿科IBD患者的不良临床结果相关.
研究的目的:
- 确定与儿科IBD身体组成缺陷相关的风险因素的患病率.
- 确定与IBD患有正常BMI Z-分数 (BMI-Z) 的儿童肌肉量低相关的因素.
主要方法:
- 对516名新诊断的IBD患者 (5-20岁) 进行了双能量X射线吸收仪扫描 (2014-2019年) 的回顾性分析.
- 尾肌瘦软组织质量指数 (AppLSTMI) 和脂肪质量指数 (FMI) 被计算为特定于年龄和性别的Z-score.
- 后勤回归分析了临床/人口统计数据和身体组成结果之间的关联.
主要成果:
- 26%的患者具有较低的尾瘦软组织质量指数 (AppLSTMI-Z < -2),而只有4%的患者具有较低的BMI-Z.
- 低AppLSTMI-Z与克罗恩病,亚裔,活跃疾病,血小板升高和葡萄糖皮质激素使用有关.
- 低肌肉质量与正常的BMI-Z与克罗恩病,亚裔和黑人种族以及血小板升高有关.
结论:
- 体重指数 (BMI) 是对儿科IBD的身体组成的不充分衡量,通常隐藏着普遍存在的肌肉质量缺陷.
- 需要进一步的研究,以了解长期影响和潜在的可逆性,在儿科IBD瘦体质量赤字.
相关概念视频
01:30Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
288
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
288
01:30Inflammatory Bowel Disease II: Crohn's Disease
138
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
138
01:27Inflammatory Bowel Disease I: Ulcerative Colitis
103
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
103
01:17Chronic Bowel Disorders: Introduction
373
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
373
01:17Irritable Bowel Syndrome I: Introduction
211
Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
211
01:21Inflammatory Bowel Disease V: Surgical Management
70
Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
Here are some common surgical interventions for IBD:
70