在大型电子健康记录系统中,听力损失和痴呆症之间的关联
Lauren H Tucker1, Maeher R Grewal2, Alexander Chern3
1Department of Otolaryngology-Head and Neck Surgery, Columbia University Vagelos College of Physicians and Surgeons, NewYork-Presbyterian/Columbia University Irving Medical Center, New York, New York, USA.
The Laryngoscope
|May 19, 2025
概括
听力测量听力损失,即使是轻微的,也与更高的痴呆风险有关. 这项研究使用电子健康记录来显示听力障碍和痴呆率增加之间存在显著的关联.
科学领域:
- 听力学 听力学是指听力学.
- 神经学 神经学
- 流行病学 流行病学
背景情况:
- 听力损失研究的国家数据集受少数变量和严重疾病的参与者限制.
- 电子健康记录 (EHR) 为大规模流行病学研究提供了有价值的替代方案.
研究的目的:
- 通过使用大型EHR数据集,调查声度听力损失和痴呆症之间的关联.
- 通过使用全面的临床数据来克服先前研究的局限性.
主要方法:
- 这是一项涉及哥伦比亚大学和康奈尔大学医学中心31,997名参与者的横截面,多中心的回顾性研究.
- 从更好的耳朵分析了听力测量指标 (纯音调平均值,词识别得分,语音接收值).
- 痴呆症是通过ICD-10代码,药物清单或两者一起识别的. 对年龄,性别和心血管风险评分进行控制的后勤回归.
主要成果:
- 听力测量结果显示,听力恶化与痴呆的几率增加有关.
- 对于每10dB的纯音调平均值恶化,痴呆的几率增加了1.11 (95% CI:1.07-1.16).
- 对于每10%的词识别得分恶化,痴呆的几率增加1.06 (95%CI:1.01-1.11).
- 对于每10dB的语音接收值恶化,痴呆的几率增加了1.10 (95% CI:1.05-1.15).
结论:
- 以多种方式定义的听力测量听力损失与痴呆的几率增加有显著的关联.
- 大型电子听力系统可以有效地支持和扩大对听力损失及其伴随疾病 (如痴呆症) 的研究.
相关概念视频
Dementia
76
Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....
The progression of dementia is generally gradual....
76
Hearing
51.6K
When we hear a sound, our nervous system is detecting sound waves—pressure waves of mechanical energy traveling through a medium. The frequency of the wave is perceived as pitch, while the amplitude is perceived as loudness.
51.6K
Alzheimer's Disease: Overview
396
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
396


