药物先验生长激素缺乏儿童中小世界网络的破坏:基于DTI的网络分析
Yasen Alimire1,2, Yanglei Cheng3, Huaqiong Qiu1
1Department of Radiology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Quantitative imaging in medicine and surgery
|May 19, 2025
概括
患有生长激素缺乏症 (GHD) 的儿童表现出被破坏的白质 (WM) 结构连接性. 这些大脑网络的改变可能是行为问题的基础,并且与受损的GH/IGF-1轴功能有关.
科学领域:
- 神经成像是一种神经成像.
- 发育神经科学的发展神经科学.
- 系统神经科学 系统神经科学
背景情况:
- 儿童的生长激素缺乏症 (GHD) 损害了生长激素/胰岛素类生长因子-1 (GH/IGF-1) 轴.
- 虽然GHD对大脑结构和功能的影响已知,但其对白质 (WM) 结构连接性的影响尚不清楚.
- 这项研究调查了儿科GHD中的WM结构连接体组织.
研究的目的:
- 检查GHD儿童WM结构连接体的拓组织.
- 为了比较患有GHD的儿童和典型发育 (TD) 的儿童之间的WM网络属性.
- 探索网络变化与临床症状严重程度之间的关系.
主要方法:
- 对58名患有GHD的儿童和30名TD对照者的横截面研究.
- 扩散张力成像 (DTI) 和确定性曲谱用于评估结构连接性.
- 图形理论分析用于评估拓参数和网络指标.
主要成果:
- 与TD对照组相比,GHD患者表现出改变的全球网络特性,包括增加特征路径长度和降低全球和本地效率.
- 在GHD中,与主要大脑网络 (DMN,CEN,VN,SN,SMN),基底和左丘脑相关的区域观察到异常的节点参数.
- 特定大脑区域的节点效率与GHD儿童的行为检查清单得分相关.
结论:
- 患有GHD的儿童表现出被破坏的WM拓组织.
- 这些干扰可能与异常的GH/IGF-1水平有关,并与行为问题有关.
- 改变的结构性大脑网络为GHD行为挑战的神经生物学基础提供了洞察力.
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