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相关概念视频

Cotranslational Protein Translocation01:20

Cotranslational Protein Translocation

7.0K
Translocation of proteins across membranes is an ancient process that occurs even in bacteria and archaebacteria. In fact, the components of the translocation machinery are still conserved between prokaryotes and eukaryotes.
Sec61 channel partners for cotranslational translocation
During cotranslational translocation, the Sec61 channel partners with the signal recognition particle (SRP), the signal recognition particle receptor (SR), and the ribosomes to transport the nascent polypeptide chain...
7.0K
Initiation of Translation02:33

Initiation of Translation

30.0K
Initiating translation is complex because it involves multiple molecules. Initiator tRNA, ribosomal subunits, and eukaryotic initiation factors (eIFs) are all required to assemble on the initiation codon of mRNA. This process consists of several steps that are mediated by different eIFs.
First, the initiator tRNA must be selected from the pool of elongator tRNAs by eukaryotic initiation factor 2 (eIF2). The initiator tRNA (Met-tRNAi) has conserved sequence elements including modified bases at...
30.0K
Leaky Scanning02:28

Leaky Scanning

5.0K
During most eukaryotic translation processes, the small 40S ribosome subunit scans an mRNA from its 5' end until it encounters the first start AUG codon. The large 60S ribosomal subunit then joins the smaller one to initiate protein synthesis. The location of the translation initiation is largely determined by the nucleotides near the start codon as there may be multiple translation initiation sites present on the mRNA.  Marilyn Kozak discovered that the sequence RCCAUGG (where R...
5.0K
Translation01:31

Translation

141.1K
Lesson: Translation
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of...
141.1K
Improving Translational Accuracy02:07

Improving Translational Accuracy

8.5K
Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...
8.5K

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相关实验视频

Updated: May 21, 2025

Working with Human Tissues for Translational Cancer Research
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Working with Human Tissues for Translational Cancer Research

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在基础和早期的翻译研究中嵌入对公平的全球准入的承诺.

Barry S Coller1

  • 1Rockefeller University, New York, NY, USA.

Journal of clinical and translational science
|May 19, 2025
PubMed
概括
此摘要是机器生成的。

随着COVID-19的流行,医疗保健方面的不平等问题得到了突出突出. 本次审查建议将公平的视角纳入早期研究,重点关注专利和许可策略,以确保全球获得新医疗技术.

关键词:
技术转让 技术转让 技术转让卫生公平性健康公平性许可证 许可证 许可证 许可证 许可证制造业 制造业 是一个制造业.patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent

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A Protocol for Using Gene Set Enrichment Analysis to Identify the Appropriate Animal Model for Translational Research
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Leveraging CyVerse Resources for De Novo Comparative Transcriptomics of Underserved Non-model Organisms
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相关实验视频

Last Updated: May 21, 2025

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科学领域:

  • 翻译研究是翻译研究.
  • 卫生公平性健康公平性
  • 知识产权管理知识产权管理

背景情况:

  • 随着COVID-19大流行,全球在医疗保健获取和技术方面出现了重大不平等现象.
  • 越来越需要在医疗保健研究和开发的各个方面应用公平的镜头.

研究的目的:

  • 在洛克菲勒大学推出一项倡议,促进全球平等获得研究发现的机会.
  • 专注于早期翻译研究的专利和许可策略.
  • 为发明者提供指导,帮助他们最大限度地获得全球新技术.

主要方法:

  • 审查专利和许可的现有做法.
  • 制定一个框架,考虑公平的全球准入.
  • 为发明家和技术转让官员制定关键问题.

主要成果:

  • 确定专利和许可作为确保公平获取的关键方面.
  • 建议发明者在技术许可讨论期间考虑十个问题.
  • 强调从基础研究的早期阶段就解决公平问题的重要性.

结论:

  • 将公平的视角纳入翻译性研究对于解决全球健康差异至关重要.
  • 战略性专利和许可对于促进新医疗技术传播至关重要.
  • 积极的规划是必要的,以确保在低收入和中等收入国家获得公平的创新机会.