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Updated: May 21, 2025

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调节免疫抑制瘤微环境并通过STAT3路径阻塞抑制Mutp53-驱动CRPC的生长

Zichen Bian1, Jia Chen1, Yufan Wang1

  • 1Department of Urology, The First Affiliated Hospital of Anhui Medical University; Institute of Urology, Anhui Medical University; Anhui Province Key Laboratory of Urological and Andrological Diseases Research and Medical Transformation, Anhui Medical University, Hefei, 230022, China.

International journal of biological sciences
|May 19, 2025
PubMed
概括

TP53突变,特别是p.R248Q,通过创建免疫抑制瘤微环境 (TME) 来驱动抵抗割的前列腺癌 (CRPC). 用抑制剂向STAT3途径可以减少这种免疫抑制并减缓CRPC的进展.

关键词:
在STAT3信号传输中.这就是TP53的特点.割抗性前列腺癌是什么?免疫抑制的微环境p.R248QQ 在线阅读

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