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瘤中RNA结合蛋白和非编码RNA之间的交叉:分子机制和临床意义

Shiwen Cui^1,2,3, Qiu Peng^1,2, Qianfeng Ma^1,2

¹Hunan Key Laboratory of Cancer Metabolism, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, 410013, Hunan, China.

International journal of biological sciences

|May 19, 2025

概括

RNA结合蛋白和非编码RNA在瘤进展中至关重要. 本综述探讨了它们的复杂相互作用,揭示了对瘤发生和潜在治疗点的见解.

科学领域:

分子生物学分子生物学
癌症生物学癌症生物学
遗传学遗传学是一个

背景情况:

RNA结合蛋白 (RBPs) 和非编码RNA (ncRNAs) 是基因表达的关键调节者.
RBPs和ncRNA都在瘤发育和进展中发挥着关键作用.
在癌症中,RBP和ncRNA的复杂网络和协作功能仍然不完全理解.

研究的目的:

提供RBPs及其相关ncRNAs在瘤生物学中的作用的全面审查.
探索RBPs和ncRNAs影响瘤进展的机制.
在各种癌症特征中阐明RBPs和ncRNA之间的交互网络.

主要方法:

文献综述和现有研究结果的综合.
在与癌症相关的过程中分析特定RBP的功能 (例如,替代拼接,m6A修饰).
检查各种ncRNAs (miRNAs, lncRNAs, circRNAs) 在瘤发生中的作用.

主要成果:

RBPs参与了关键的细胞过程,如瘤中的替代拼接,m6A修饰和相分离.
ncRNAs,包括microRNAs,长非编码RNAs和circRNAs,显著影响瘤的进展.
RBPs和ncRNA之间的相互作用影响代谢重编程,免疫力,耐药性,转移和铁亡.

结论:

了解RBPs和ncRNAs的协作功能对于理解瘤发生至关重要.
RBP-ncRNA网络为开发新型癌症治疗策略提供了有前途的途径.
对这些相互作用的进一步研究将进一步深入了解癌症机制和治疗可能性.

关键词:

RNA结合蛋白质是RNA结合的蛋白质.没有编码的RNAs.阶段分离的阶段分离.拼接拼接拼接拼接瘤免疫力免疫力

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