卵巢癌患者同时发生阴道炎的感染特征和危险因素
Xiaoping Feng1, Ping Wu1, Fenghua Chen1
1Department of Gynecology, Yiwu Central Hospital Jinhua 322000, Zhejiang, China.
American journal of translational research
|May 19, 2025
概括
阴道感染,主要是 vulvovaginal candidasis,影响34%的卵巢癌患者. 关键的风险因素包括教育,性行为频率,淋浴和先前的阴道炎史.
科学领域:
- 妇科瘤学 妇科瘤学
- 传染性疾病 传染性疾病
- 阴道微生物组研究
背景情况:
- 卵巢癌 (OC) 患者可能会出现并发性阴道炎,可能会影响他们的健康结果.
- 了解OC患者阴道炎的特征和危险因素对于有效管理至关重要.
研究的目的:
- 为了研究卵巢癌患者的感染特征与阴道炎.
- 在这个患者群体中确定与阴道感染相关的独立风险因素.
主要方法:
- 对100名卵巢癌患者的临床数据进行了回顾性分析.
- 根据阴道炎的存在分类为感染 (n=34) 和非感染 (n=66) 组.
- 评估感染类型,血清HE4和阴道内白蛋白 (IL) -4,IL-6,IL-10水平;对风险因素进行后勤回归和ROC曲线分析.
主要成果:
- 34%的OC患者患有阴道炎, vulvovaginal candidiasis是最常见的类型 (29.41%),其次是细菌性阴道炎 (23.53%).
- 与非感染组相比,感染组中观察到 IL-4,IL-6 和 IL-10 水平升高.
- 确定了独立的风险因素:教育水平,性行为频率,自我阴道冲洗和阴道炎史 (AUC=0.858用于关节预测).
结论:
- 性阴道角膜炎和细菌性阴道炎是卵巢癌患者普遍存在的阴道感染.
- 教育,性行为频率,浴习惯和先前的阴道炎病史是OC患者阴道感染的重要影响因素.
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