血中热素T反映了低运动神经元参与的电肌谱在肌缩性侧面硬化症
Sanharib Chamoun1,2, Sofia Imrell3, Zane Upate4
1Department of Neurology, Karolinska University Hospital, Stockholm, Sweden.
高灵敏的心脏托罗素T (hs-cTnT) 与低运动神经元 (LMN) 在肌缩侧面硬化症 (ALS) 的参与相关. 这表明hs-cTnT可能作为ALS患者LMN疾病进展的生物标志物.
科学领域:
- 神经学 神经学
- 心脏病学 心脏病学
- 生物标志物发现发现
背景情况:
- 升高的心脏托罗素T (cTnT) 在神经肌肉疾病中观察到,例如没有明显的心脏病的肌缩性侧面硬化症 (ALS).
- 在ALS中cTnT升高的来源尚不清楚,骨肌肉与心肌细胞一起是潜在的贡献者.
研究的目的:
- 研究骨肌肉作为ALS患者中cTnT的来源.
- 通过电肌图 (EMG) 评估cTnT水平和下部运动神经元 (LMN) 参与之间的相关性.
- 确定cTnT是否可以作为LMN参与ALS的生物标志物.
主要方法:
- 在第三级推中心对50名ALS患者的观察队列研究.
- 在EMG后六个月内分析高灵敏性心脏托邦素T (hs-cTnT),肌酸激酶 (CK) 和神经纤维光 (NfL).
- 对hs-cTnT水平,EMG发现 (所涉及的肌肉区域和百分比),国王阶段和ALSFRS-R得分之间的相关性分析.
主要成果:
- Hs-cTnT与EMG所涉及的肌肉的数量和百分比呈正相关性 (p=0.009).
- 在ALS患者中,较高的hs-cTnT水平与更先进的King's阶段有关.
- 在单变量分析中,hs-cTnT与ALSFRS-R得分没有相关性,并且显示出预测短生存时间的趋势.
结论:
- 在ALS患者中hs-cTnT升高与更广泛的疾病有关,如EMG和King的阶段所示.
- Hs-cTnT似乎是一个反映LMN参与ALS的生物标志物,与肌肉或神经轴损伤标志物不同.
- 需要在更大的研究中进一步验证,但hs-cTnT有可能用于ALS的临床试验.
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