在没有先前自杀倾向的自杀者中,对神经精神疾病有不同的遗传责任
medRxiv : the preprint server for health sciences
|May 19, 2025
概括
没有先前尝试的自杀死亡显示出不同的遗传特征,特别是神经精神疾病的较低多基因分数. 这一发现需要对自杀死亡率高风险的个人进行新的研究和预防策略.
科学领域:
- 遗传学 是一个遗传学.
- 精神病学是一个精神病学.
- 死亡率研究 死亡率研究
背景情况:
- 自杀企图是自杀死亡的强有力的预测因素,但约50%的自杀死亡发生在没有先前尝试的情况下.
- 没有先前非致命的自杀行为的人的风险是不太了解的.
研究的目的:
- 在没有先前非致命的自杀思想或行为 (SD-N) 的自杀死亡中调查潜在的多基因负债 (PGS),与先前自杀倾向 (SD-S) 的人相比.
- 确定可能解释未曾有过自杀想法或尝试的个体中自杀死亡率的遗传差异.
主要方法:
- 利用了来自犹他州自杀死亡风险研究 (USMRS) 的数据.
- 在SD-N,SD-S和人口对照之间对12种神经精神疾病的多基因分数 (PGS) 的比较.
- 采用协同变量的分析,根据性别,年龄和遗传血统进行调整.
主要成果:
- 在死亡时,SD-N比SD-S更为男性,年龄更大.
- 与SD-S相比,SD-N对主要抑郁症,神经病,焦虑症,阿尔茨海默氏症,精神分裂症,PTSD和双相情感障碍的PGS显著较低.
- 在SD-N中减弱的PGS特别被注意为抑郁情绪,神经病症和阿尔茨海默氏症,与对照没有差异.
结论:
- 没有先前自杀倾向的自杀死亡与先前尝试的人相比,具有明显的遗传负债.
- 这些发现挑战了对心理健康风险的传统关注,并建议探索非精神病学因素.
- 结果对未来的自杀研究和针对高危人群的预防工作有重大影响.
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