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慢性病中高血的负担:一个系统的文献综述
Jürgen Floege1, Andrew H Frankel2, Kevin F Erickson3
1Division of Nephrology and Dept of Cardiology, RWTH Aachen University, Aachen, Germany.
Clinical kidney journal
|May 19, 2025
概括
慢性病 (CKD) 患者的高血是常见的,并且与不良结果有关. 管理这种情况,特别是使用氨酸-血管氨酸-氨系统抑制剂 (RAASi),需要仔细考虑,因为它对健康和经济产生重大影响.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 药理学 药理学是指药理学的学科.
- 公共卫生 公共卫生
背景情况:
- 高血是慢性病 (CKD) 患者的常见并发症.
- 不一致的定义掩盖了真正的全球流行病学和高血症的负担.
- 由于副作用和药物相互作用,了解高血症至关重要,特别是与氨酸-氨酸-阿尔多斯特系统抑制剂 (RAASi) 的相互作用.
研究的目的:
- 系统地审查和总结关于成人慢性病患者高血症危险因素的证据.
- 描述与高血症相关的特征,包括非最佳RAASi使用的影响.
- 探索慢性病中高血的临床和经济结果.
主要方法:
- 对Medline和Embase数据库 (2000-2024) 的系统文献综述,使用手动搜索.
- 由两个独立审查员进行选;由独立审查员进行数据提取和质量评估.
- 标识研究的描述性总结.
主要成果:
- 138项研究 (145篇出版物) 符合资格标准.
- 超血的患病率因定义而异,但在CKD患者中显著增加,无论RAASi治疗如何.
- 高血症与不良结果,医疗资源利用率增加和负面经济影响有关,特别是在心力衰竭或没有心力衰竭的慢性病患者中,RAASi剂量低于最佳.
结论:
- 本综述提供了CKD中高血症的全面概述,重点关注临床和经济结果.
- 超血症风险和亚最佳RAASi剂量之间的相互作用需要进一步研究.
- 临床医生必须在治疗慢性病患者的高血症时保持谨慎.
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