Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Effectiveness of Peritoneal Lavage in Reducing Postoperative Pain in Elective Laparoscopic Cholecystectomy: A Prospective Cohort Study.

Medical sciences (Basel, Switzerland)·2026
Same author

Establishment of a Thioacetamide-Induced Hepatotoxicity Model in Synanthropic Rats with Translational Relevance.

Diseases (Basel, Switzerland)·2026
Same author

Post-Pandemic Resurgence and Seasonal Patterns of Influenza Viruses and Respiratory Syncytial Virus in Arequipa, Peru (2021-2023).

Epidemiologia (Basel, Switzerland)·2026
Same author

Population-Specific Pharmacogenomic Profiling of <i>NAT2</i>, <i>CYP2E1</i>, and <i>SLCO1B1</i> in Tuberculosis Patients from Southern Peru: A Feasibility Pilot Study.

Journal of personalized medicine·2026
Same author

Integrated Functional and Histopathological Modulation of Chronic Thioacetamide-Induced Liver Fibrosis by Mesenchymal Stem Cell Therapy in a Preclinical Model.

Diseases (Basel, Switzerland)·2026
Same author

High Consumption of Ultra-Processed Foods Is Associated with Genome-Wide DNA Methylation Differences in Women: A Pilot Study.

Nutrients·2025

相关实验视频

Updated: Jun 19, 2026

Building Up a High-throughput Screening Platform to Assess the Heterogeneity of HER2 Gene Amplification in Breast Cancers
11:34

Building Up a High-throughput Screening Platform to Assess the Heterogeneity of HER2 Gene Amplification in Breast Cancers

Published on: December 5, 2017

12.4K

闪亮的应用程序:闪亮的瘤高通量基于omics的路线图.

Eduardo Navarrete-Bencomo1,2, Anthony Vladimir Campos Segura3,4,5, Orlando R Sevillano6

  • 1Unidad Profesional Interdisciplinaria de Biotecnología del Instituto Politécnico Nacional, Av. Luis Enrique Erro S/N, Zacatenco, Alcaldía Gustavo A. Madero, Ciudad de México, CP 07738, México.

Bioinformatics advances
|May 19, 2025
PubMed
概括

ShinyTHOR提供了一个用户友好的网络应用程序,用于探索来自癌症细胞系的多组和药物反应数据. 这种工具提高了研究人员的可访问性,促进了对癌症生物学和药物敏感性的更深入的了解.

更多相关视频

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis
07:41

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis

Published on: March 8, 2022

2.4K
Author Spotlight: Finding New Therapeutic Targets for Malignant Peripheral Nerve Sheath Tumor Through Genome-Scale shRNA Screens
09:33

Author Spotlight: Finding New Therapeutic Targets for Malignant Peripheral Nerve Sheath Tumor Through Genome-Scale shRNA Screens

Published on: August 25, 2023

1.1K

相关实验视频

Last Updated: Jun 19, 2026

Building Up a High-throughput Screening Platform to Assess the Heterogeneity of HER2 Gene Amplification in Breast Cancers
11:34

Building Up a High-throughput Screening Platform to Assess the Heterogeneity of HER2 Gene Amplification in Breast Cancers

Published on: December 5, 2017

12.4K
A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis
07:41

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis

Published on: March 8, 2022

2.4K
Author Spotlight: Finding New Therapeutic Targets for Malignant Peripheral Nerve Sheath Tumor Through Genome-Scale shRNA Screens
09:33

Author Spotlight: Finding New Therapeutic Targets for Malignant Peripheral Nerve Sheath Tumor Through Genome-Scale shRNA Screens

Published on: August 25, 2023

1.1K

科学领域:

  • 癌症研究 癌症研究
  • 生物信息学是一种生物信息学.
  • 基因组学就是基因组学.

背景情况:

  • 癌症细胞系百科全书 (CCLE) 为超过1000个癌症细胞系提供了广泛的多组和药物反应数据.
  • 像DepMap这样的当前工具缺乏针对不同分子数据类型和药物反应的综合分析能力.
  • 访问和比较这些复杂的数据往往需要专门的生物信息学专业知识,限制了许多研究人员的使用.

研究的目的:

  • 开发ShinyTHOR,一个直观的Web应用程序,用于访问和分析来自癌症细胞系的多组和药物相关数据.
  • 将CCLE,miRTarBase,circInteractome和癌症药物敏感性基因组学 (GDSC) 的数据集成到一个平台上.
  • 为研究人员提供基因表达,药物敏感性和分子相互作用的比较分析工具.

主要方法:

  • 使用Shiny框架开发一个Web应用程序.
  • 整合各种数据集,包括转录组,代谢组,甲基组,蛋白组和miRNomic数据.
  • 实施六个不同的分析模块来探索细胞系数据,基因组,分子相互作用和药物反应.

主要成果:

  • 闪亮THOR提供了直观的访问多组和药物敏感性数据.
  • 该应用程序可以对分子标记物,药物IC50值和基因组丰富进行比较分析.
  • 模块方便探索miRNA-目标相互作用,miRNA对翻译的影响以及circRNA/miRNA调制.
  • 使用胃癌预后研究 (GES7) 的验证证明了该工具的实用性.

结论:

  • ShinyTHOR使更广泛的研究社区能够获得复杂的癌症细胞系数据.
  • 该网络应用程序促进了癌症生物学和精准医学中的假设生成和发现.
  • 对于研究癌症细胞系依赖性和药物反应的研究人员来说,ShinyTHOR 是一个宝贵的资源.