病理边缘对基底细胞癌复发的影响:毫米是否重要?
Shahd Nour1,2, Dalia Mohamed1, Ouali Braham1
1Plastic and Reconstructive Surgery, Dudley Group NHS Foundation Trust, Birmingham, GBR.
Cureus
|May 19, 2025
概括
达到1毫米以上的基底细胞癌 (BCC) 切除边缘,与较窄的边缘相比,可使复发风险减少一半以上. 这一发现支持最佳BCC管理的更广泛的外科手术边缘.
科学领域:
- 在瘤学瘤学.
- 皮肤病学 皮肤病学
- 手术病理学手术病理学
背景情况:
- 基底细胞癌 (BCC) 是全球最常见的皮肤癌.
- 现有的关于BCC边缘和复发的研究缺乏长期数据和一致的体系病理学确认,造成了对最佳手术实践的不确定性,特别是在英国.
研究的目的:
- 评估基因病理边缘宽度对BCC复发率的影响.
- 为了比较BCCs之间的复发率,以≤1毫米的利率与>1毫米的利率减免.
- 评估七年随访期间的复发模式,并为外科手术指南提供信息.
主要方法:
- 对2005年1月至2006年12月期间的BCC诊断的组织病理学数据库的分析.
- 对965名患者记录,记录人口统计,病变特征,边缘宽度和7年复发数据的审查.
- 狭窄 (≤1毫米) 和宽 (>1毫米) 边缘组之间的复发率的统计比较.
主要成果:
- 观察到复发率的统计学上显著差异:狭窄边缘 (≤1毫米) 的4.8%,宽边缘 (>1毫米) 的2.0% (p = 0.017).
- 达到大于1毫米的边际将BCC复发风险降低了一半以上.
- 在这项研究中,瘤部位和亚型没有显著影响复发率.
结论:
- 组织病理边缘宽度是BCC复发的一个关键因素.
- 切割边缘大于1毫米与BCC复发风险明显降低有关.
- 这些发现支持采用更宽的外科手术边缘,以改善BCC管理并减少复发.
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