在新诊断的高血压患者中,泛免疫-炎症值和Dipper/Non-Dipper状态之间的关联
Muhammet Salih Ateş1, Alp Yıldırım1, Erdoğan Sökmen1
1Department of Cardiology, Kırsehir Ahi Evran Education and Research Hospital, Kırsehir, Turkey.
Journal of inflammation research
|May 19, 2025
概括
升高的泛免疫炎症值 (PIV) 与非滴水性高血压有关,表明夜间血压下降受损. 这表明PIV可能有助于识别高血压风险并指导个性化治疗.
科学领域:
- 心脏病学 心脏病学
- 炎症研究 炎症研究
- 生物标志物发现发现
背景情况:
- 循环血压 (BP) 模式,特别是夜间BP下降,是关键的心血管风险指标.
- 系统性炎症因其在心血管疾病 (包括高血压) 中的作用而越来越被认可.
- 全免疫炎症值 (PIV) 是一种反映系统性炎症的新标志物.
研究的目的:
- 在新诊断的高血压患者中,调查泛免疫炎症值 (PIV) 和滴水/非滴水状态之间的关联.
- 探讨提升PIV水平与夜间血压下降的高血压相关的假设.
主要方法:
- 前性研究包括725名新诊断的高血压患者和343名对照.
- 根据24小时的门诊血压监测 (ABPM) 将高血压患者分为滴水 (n=339) 和非滴水 (n=386) 的分类.
- 计算PIV为 (中性细胞数 × 血小板数 × 单细胞数) / 淋巴细胞数,然后进行多变量逻辑回归和ROC曲线分析.
主要成果:
- 在非滴滴高血压患者中,PIV明显高于滴滴高血压患者 (p<0.001).
- 在对共变量进行调整后,最高的PIV四分位数 (Q4) 独立与非浸泡状态相关 (OR:12.56,95% CI:7.31-21.56,p<0.001).
- ROC分析表明PIV截止值为326.96预测的非浸泡状态,灵敏度为70.5%和特异性为65.5% (AUC:0.725,p<0.001).
结论:
- 升高的PIV水平与非滴水高血压显著相关,突出显示了系统性炎症在昼夜血压调节失调中的作用.
- 在高血压患者中,PIV可以作为风险分层的有价值生物标志物.
- 这些发现支持PIV在开发高血压个性化治疗策略方面的潜力.
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