相对脂肪量与结直肠癌之间的关联:一个横截面研究
Yaping Wang1, Shilong Song2, Lu Zhang1
1Department of Medical Oncology, The First Affiliated Hospital of Bengbu Medical University, Bengbu, China.
Frontiers in nutrition
|May 19, 2025
概括
较高的相对脂肪量 (RFM) 与美国成年人结肠直肠癌 (CRC) 风险增加有关. 这种关联因性别而异,因年龄而变化,突出显示RFM是潜在的CRC指标.
科学领域:
- 公共卫生 公共卫生
- 流行病学 流行病学
- 肥胖问题研究研究
背景情况:
- 肥胖是一个日益严重的公共卫生问题.
- 了解身体成分与癌症风险之间的关系至关重要.
- 相对脂肪质量 (RFM) 是评估脂肪的新兴指标.
研究的目的:
- 调查相对脂肪量 (RFM) 与结直肠癌 (CRC) 患病率之间的联系.
- 探索这种关联中的潜在的性别特异性差异.
- 检查年龄对RFM-CRC关系的影响.
主要方法:
- 从国家健康和营养检查调查 (NHANES) (1999-2020) 的数据分析.
- 包括52,281名20岁及以上的美国成年人.
- 利用多重逻辑回归,平滑曲线拟合,子组分析和相互作用测试.
主要成果:
- 在RFM和CRC之间发现了显著的积极关联 (OR=1.03,95%CI:1.01,1.06).
- 在男性中观察到线性正相关性,而在女性中观察到非线性相关性, RFM=42的拐点.
- 年龄被确定为RFM-CRC关联的显著修饰因素 (P-相互作用=0.0085).
结论:
- 相对脂肪量 (RFM) 与美国成年人结肠直肠癌 (CRC) 患病率有显著的关联.
- RFM和CRC之间的关系在男性和女性之间有所不同,并受年龄的影响.
- 需要进一步的前性研究来证实这些发现.
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