作为医院住院COVID-19患者的预后生物标志物的甲的作用:比较分析
Shahin Isha1, Lekhya Raavi1, Sadhana Jonna1
1Department of Critical Care Medicine, Mayo Clinic in Florida, Jacksonville, FL, USA.
Biomarker insights
|May 19, 2025
概括
在COVID-19患者中,高甲素 (PCT) 水平与ICU入院和死亡率等严重结果相关. 将PCT与其他生物标志物的结合提高了风险评估的预测准确性.
科学领域:
- 关键护理医学 关键护理医学
- 传染性疾病 传染性疾病
- 生物标志物研究 生物标志物研究
背景情况:
- 甲素 (PCT) 是一种炎症生物标志物,在COVID-19肺炎中经常升高.
- 了解PCT与严重结果的关联对于临床管理至关重要.
- 将PCT的预测能力与其他生物标志物的比较至关重要.
研究的目的:
- 研究住院COVID-19患者的PCT水平和不良结果之间的关联.
- 将PCT与其他生物标志物的预测性能进行比较.
- 评估生物标志物组合对风险分层的有用性.
主要方法:
- 使用SCCM VIRUS注册表进行的回顾性多中心观察研究.
- 包括7851名在2020年3月至2022年6月期间住院的成年COVID-19患者.
- 在入院72小时内,使用调整为混因子的多变量模型分析了生物标志物的峰值水平.
主要成果:
- 较高的PCT水平独立地与增加ICU入院,IMV和住院死亡率的几率有关.
- 峰值PCT≥0.25 ng/mL显示IMV增加3.48倍,死亡率增加3.55倍.
- 包括NLR,LDH,D-二聚合物和PCT在内的组合模型实现了最高的预测准确性 (AUC 0.826).
结论:
- 升高的PCT显著与COVID-19患者的更差结果有关,作为预后标志物.
- 基于生物标志物的预测模型,特别是包括PCT在内的预测模型,对风险评估充满希望.
- 需要进一步的前性研究来更大规模验证这些发现.
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