饮食中服用menaquinone-9补充剂不会影响小鼠骨发育期间的骨组织质量或骨矿物质密度
Minying Liu1, Chongshan Liu2,3, Nicolas Cevallos2
1USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, United States.
JBMR plus
|May 19, 2025
概括
维生素K的一种形式menaquinone-9 (MK9) 在小鼠身上对骨健康的影响进行了研究. 补充剂没有改善骨质或骨密度,尽管MK9在骨中转化为MK4.
科学领域:
- 营养生物化学 营养生物化学
- 骨生理学 骨生理学
- 维生素K的代谢 维生素K的代谢
背景情况:
- 维生素K对骨健康至关重要,研究主要集中在基和基-4 (MK4) 上.
- 细菌产生的维生素K形式,如menaquinone-9 (MK9),研究较少,但可能会影响骨健康.
研究的目的:
- 研究menaquinone-9 (MK9) 补充剂对年轻小鼠骨组织质量和密度的影响.
- 确定MK9在骨组织中的代谢命运及其与MK4水平的关系.
主要方法:
- 年轻的雄性和雌性小鼠在12周内被食,并补充了两种不同度的MK9.
- 用乳标记的MK9被用于追踪其转化和存在于骨组织中的情况.
- 分析了骨组织质量 (强度,密度,横截面特性) 和MK4/MK9水平.
主要成果:
- 在小鼠中,较高的MK9摄入量增加了肝脏MK4和MK9度.
- MK4是骨中占主导地位的维生素K形式,其中很大一部分来自标记的MK9.
- 在饮食组之间没有观察到大腿组织强度或骨质量 (BMD) 的显著差异.
- 接受更高MK9的雌性小鼠显示了截面面积和惯性瞬间的减少,与雄性不同.
结论:
- 饮食MK9在骨组织中作为MK4的前体.
- 在这种小鼠模型中,MK9补充剂在骨发育过程中没有提高骨组织质量或密度.
- 需要进一步的研究,以了解不同menaquinones在骨健康中的具体作用.
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