经更年期妇女患有骨质疏松症的身体构成和高血压之间的关系 - - 一个单一中心的截面研究
1Department of Echocardiography and Cardiology, The First People's Hospital of Changzhou, Changzhou, Jiangsu Province, 213003, People's Republic of China.
概括
身体脂肪质量和内脏脂肪区域是患有骨质疏松症的绝经后妇女高血压的关键指标. 使用身体组成的预测模型有效地识别高血压风险并影响静缩血压.
科学领域:
- 内分泌学 在内分泌学.
- 老年学是一门学科.
- 心血管健康 心血管健康
背景情况:
- 骨质疏松症是绝经后妇女普遍存在的疾病.
- 高血压经常与骨质疏松症并存,增加心血管风险.
- 在这个人口群体中,了解身体成分和高血压之间的关系对于风险分层至关重要.
研究的目的:
- 为了调查身体组成参数与患有骨质疏松症的绝经后妇女高血压的存在之间的关联.
- 在这个患者群体中确定高血压的独立预测因子.
- 开发和验证基于人体组成的高血压预测模型.
主要方法:
- 一项比较研究将绝经后骨质疏松症患者分为高血压阴性和高血压阳性组.
- 后勤回归分析确定了高血压的独立影响因素.
- 使用身体组成参数 (BMI,WC,BFM,PBF,VFA) 构建了一个预测模型,并使用ROC分析进行验证.
- 一般化的增材模型评估了预测因素和血压之间的关系.
主要成果:
- 在年龄,维生素D,尿酸,同类蛋白,糖尿病史,高脂胆固醇,BMI,WC,体脂肪量 (BFM),体脂肪百分比 (PBF) 和内脏脂肪面积 (VFA) 之间观察到显著差异.
- BFM (OR=0.46) 和VFA (OR=1.06) 被确定为高血压的独立预测因素.
- 该预测模型在检测高血压方面表现出中等准确性 (AUC=0.694).
- 预测者与静缩血压 (SBP) 有显著的剂量反应关系,但与静缩血压没有显著的剂量反应关系.
结论:
- BFM和VFA是患有骨质疏松症的绝经后妇女高血压的重要独立风险因素.
- 结合体质参数的预测模型可以帮助识别患有并发性高血压风险的患者.
- 开发的模型对管理这一群体的心血管风险有影响,特别是在SBP方面.
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