探索pH在进行手术的NEC患者分层死亡风险中的预测价值:基于PIC数据库的回顾性研究
Xue Liu1,2, Wenqiang Sun1,2, Ronghui Yu1,2
1Department of Neonatology, Children's Hospital of Soochow University, Suzhou, China.
Translational pediatrics
|May 19, 2025
概括
新生儿患有死角性肠球炎 (NEC) 的酸性pH值与较高的死亡率有关. 增加的白细胞和中性粒细胞与这些酸性pH值变化相关,这表明在预测NEC结果方面发挥了作用.
科学领域:
- 新生儿医学 新生儿医学
- 胃肠病学 胃肠病学
- 临界护理医学 临界护理医学
背景情况:
- 新生儿死性肠球炎 (NEC) 是一种严重的疾病,死亡率高,可靠的生物标志物很少.
- 酸性pH值,表明酸性和缺血,是不良NEC结果的潜在预测因素.
- 需要进一步调查pH,炎症标志物和NEC患者亚组之间的联系.
研究的目的:
- 调查pH在NEC死亡风险分层中的预后意义.
- 为了检查pH和中性粒细胞/白细胞计数在NEC患者之间的关联.
- 为了评估pH的预测值跨手术和非手术NEC患者群体.
主要方法:
- 从儿科重症监护数据集中回顾性分析临床和实验室数据.
- 将NEC患者分为手术/非手术和死亡/出院组进行分层.
- 进行跨组比较和多变量分析,以评估酸性pH的预测值.
主要成果:
- 在新生儿中观察到酸性pH,在手术和非手术组中都有致命的NEC结果.
- 多变量分析确定了酸性pH值作为手术NEC子组中不良结果的危险因素.
- 中性粒细胞和白细胞 (WBC) 的增加与NEC患者的pH值变化有关.
结论:
- 酸性pH与NEC新生儿的不良结果密切相关.
- 炎症标志物,特别是增加的白血球和中性粒细胞数量,可能与NEC的pH值变化相关.
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