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Updated: May 12, 2026

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配对突变调用和空间转录学识别了细胞社区,决定了结肠炎的瘤结果

Douglas Winton, Elisa Moutin, Linus Chang

    Research square
    |May 19, 2025
    PubMed
    概括

    慢性结肠炎的细胞环境通过促进亲癌突变的生长,影响癌症的发展. 这项研究阐明了组织修复机制如何影响炎症性肠道疾病中的瘤启动.

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    Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-Tune Virtual Microdissection09:19

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    Cancers Originate from Somatic Mutations in a Single Cell02:21

    Cancers Originate from Somatic Mutations in a Single Cell

    Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...