IBDome:一个综合的分子,组织病理和临床图谱的炎症性肠道疾病
Zlatko Trajanoski1, Christina Plattner2, Gregor Sturm1
1Medical University of Innsbruck.
Research square
|May 19, 2025
概括
这项研究整合了1002名患者的多omics数据,揭示了炎症性肠病 (IBD) 中明显的炎症特征. 这些发现有助于提高IBD的理解和个性化治疗策略.
科学领域:
- 胃肠道学和免疫学
- 计算生物学和生物信息学
- 精准医学是一门精准的医学.
背景情况:
- 炎症性肠病 (IBD),包括克罗恩病 (CD) 和性结肠炎 (UC),需要先进的诊断和治疗方法.
- 具有临床注释的多种OMC和多种模式数据对了解IBD病变发生和个性化治疗具有重大潜力.
研究的目的:
- 对1002名临床注释IBD患者和对照进行了广泛的多组和多模式分析.
- 在CD和UC中使用转录组学和蛋白质组学识别不同的炎症特征.
- 开发用于预测疾病活动和改善IBD管理的计算工具.
主要方法:
- 正常和炎症肠道组织的全外体和RNA测序.
- 血清蛋白质组学分析.
- 使用H&E染色组织图像的深度学习进行组织病理学评估.
- 综合分析多种经济和多式联运数据.
主要成果:
- 对于克罗恩氏病和性结肠炎,确定了独特的特定部位的转录性炎症特征.
- 开发出一种血清蛋白质严重性特征,与肠道分子炎症相关.
- 基于基金会模型的深度学习从组织图像准确预测了组织学疾病活动.
结论:
- 多omics数据和先进的计算方法的整合增强了对IBD的理解.
- 这些发现为精细的诊断和IBD个性化治疗策略铺平了道路.
- 这项研究证明了深度学习对于客观评估组织学疾病活动的有用性.
相关概念视频
Inflammatory Bowel Disease II: Crohn's Disease
154
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
154
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
291
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
291
Inflammatory Bowel Disease I: Ulcerative Colitis
108
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
108
Chronic Bowel Disorders: Introduction
375
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
375
Inflammatory Bowel Disease V: Surgical Management
80
Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
Here are some common surgical interventions for IBD:
80
Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
104
Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
104


