性激素在软骨组织中的作用:一个范围广泛的评论
Jeffrey L Hutchinson1, Amalie J Hutchinson2, Joy Feng1
1Department of Physiology & Pharmacology, Schulich School of Medicine and Dentistry, The University of Western Ontario London Ontario Canada.
JOR spine
|May 19, 2025
概括
性激素对与年龄相关的关节疾病,包括椎间盘 (IVD) 和关节软骨,显示出潜在的益处. 需要进一步的研究来了解机制,并优化关节退化临床使用.
科学领域:
- 肌肉骨健康和再生医学
- 内分泌学和分子生物学.
- 生物材料和组织工程
背景情况:
- 性激素用于肌肉骨疾病的临床应用正在增长.
- 性激素在关节组织,如椎间盘 (IVD),关节 (TMJ) 和关节软骨中的确切作用尚未明确.
- 对于开发有效的治疗策略而言,全面的理解至关重要.
研究的目的:
- 对现有的关于性激素及其对IVD,TMJ和关节软骨的影响的文献进行范围审查.
- 批判性地评估有关这些特定关节组织中性激素功能的当前知识.
- 发现研究中的差距,并为未来的临床应用提供信息.
主要方法:
- 进行了系统的数据库搜索,以确定相关的初级研究文章.
- 一个四步骤的协议指导了选择和审查过程.
- 两个独立的审稿人评估了大约140篇文章的性激素和目标关节组织的相关性.
主要成果:
- 关于丸激素在研究的关节组织中的作用的研究有限.
- 性激素似乎对与年龄相关的关节疾病有益,尽管动物模型的反应各不相同.
- 证据表明,生物性别之间存在类似的分子反应,在基因和蛋白质表达水平上可能具有抗炎作用,但确切的机制尚不清楚.
结论:
- 性激素,包括和雌激素,与关节组织的炎症信号有关,为关节退化提供了新的干预措施的潜力.
- 了解这些激素在不同组织,性别和年龄组的复杂生物机制,对于它们的安全和有效的临床实施至关重要.
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