生物化学参数与COVID肺炎的严重程度以及需要氧气/机械支持的相关性中的性别差异
Jelena Jankovic1, Mihailo Stjepanovic1, Nikola Maric1
1University Clinical Center of Serbia, Clinic for Pulmonology, Belgrade.
与女性相比,患有COVID-19的男性表现出较高的CRP和费里丁等炎症标志物的水平. 严重的放射性发现与增加对呼吸支的需求和炎症标志物的增加相关,这表明疾病呈现的性别差异.
科学领域:
- 传染性疾病 传染性疾病
- 医学研究 医学研究
- 公共卫生 公共卫生
背景情况:
- 随着COVID-19的流行,全球面临着重大挑战.
- 异质性疾病表现和缺乏标准化治疗需要进一步分析.
- 了解疾病模式对于未来的流行病准备至关重要.
研究的目的:
- 调查COVID-19患者的性别,实验室发现和疾病严重程度之间的相关性.
- 确定患者特征与需要呼吸辅助器械之间的关系.
- 为了确定严重的COVID-19结果的潜在风险和预后因素.
主要方法:
- 对99名确诊感染SARS-CoV-2的患者进行分析.
- 记录基线特征,包括年龄,性别和需要氧气或机械通风.
- 通过胸部CT扫描评估放射性发现的严重程度.
主要成果:
- 男性患者的C-反应蛋白 (CRP),淋巴细胞,乳酸脱酶 (LDH) 和费里丁水平显著更高.
- 严重的放射性发现 (双边肺炎,ARDS) 是常见的,只有20.2%的患者不需要氧气.
- 严重的疾病与需要高流量鼻腔管 (HFNC) 或侵入性机械通风 (IMV) 和白细胞 (WBC) 计数,LDH和费里丁的增加正相关.
结论:
- 性别之间的COVID-19呈现和实验室标记存在显著差异.
- 这些基于性别的差异可能是多因素的.
- 需要进一步的研究来阐明额外的风险和预后因素.
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