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Updated: May 22, 2025

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一个模块化多基酸合成酶thioesterase的定向进化,用于生成一个混合宏环环系统

Maria L Adrover-Castellano1, Brian J Curtis1, Jennifer J Schmidt1

  • 1Life Sciences Institute, University of Michigan, 210 Washtenaw Avenue, Ann Arbor, MI 48109-2216 (USA).

ACS catalysis
|May 19, 2025
PubMed
概括

研究人员设计了铁酶 (TE) 酶,以改善新型杂交巨乳素的产生. 定向进化增强了非自然宏循环的产量,克服了聚基酸合成酶 (PKS) 路径工程中的一个关键挑战.

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