布德塞尼德/糖皮龙/形式醇烟酸联合悬浮计量剂量吸入器缓解了叶切除术后的咳:一项随机对照研究
Junguo Dong1, Shunjun Jiang2, Yuan Qiu1
1Department of Thoracic Surgery and Oncology, The First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, Guangzhou, China.
在一项临床试验中,Budesonide/glycopyrronium/formoterol fumarate (BGF) 计量剂量吸入器有效降低了肺切除 (CAP) 后的咳. 这种治疗改善了患者的生活质量,并加快了接受带切除术的患者的康复.
科学领域:
- 肺部医学 肺部医学
- 临床药理学 临床药理学
- 呼吸道外科手术 呼吸道外科手术
背景情况:
- 肺切除后咳 (CAP) 是非标准化治疗的常见并发症.
- 众所周知,布德索尼德/甘皮龙/形式醇烟酸 (BGF) 的成分有助于治疗咳.
- 启动了一项临床试验,以评估BGF计量剂量吸入器 (MDI) 对CAP.
研究的目的:
- 评估BGF MDI在缓解CAP方面的有效性和安全性.
- 评估BGF MDI对咳严重程度,持续时间和肺切除术后生活质量的影响.
主要方法:
- 一项随机对照试验,将BGF MDI与对照组进行比较.
- 参与者接受了BGF MDI14天后的乳腺切除术,并进行了60天的随访.
- 主要终点:明显的CAP发生持续≥14天.
主要成果:
- BGF MDI显著降低了持续≥14天的CAP发生率 (13.7%与40.4%相比).
- 在BGF MDI组中,在术后14日和30日观察到与咳相关的改善生活质量.
- 在三名BGFMDI参与者中报告了心;没有其他显著的并发症.
结论:
- BGF MDI 证明了在减少 CAP 严重性和持续时间方面的有效性和安全性.
- 在手术后使用BGF MDI可缓解咳症状,加快术后恢复.
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