瘤微环境和与免疫相关的肌肉炎:在癌症免疫治疗中解决肌肉消耗问题
Shuang Ma1, Guangyu Zhao1, Shang Sui2
1School of Information Science and Engineering, Shenyang Ligong University, Shenyang, China.
Frontiers in immunology
|May 19, 2025
概括
癌症免疫疗法可以导致肌肉消耗. 本综述探讨了机制,并提出了与营养或抗炎药物结合治疗,以保持肌肉健康并改善患者的治疗结果.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 肌肉生理学 肌肉生理学
背景情况:
- 癌症免疫疗法已经取得了重大进展,提供了新的治疗途径.
- 然而,免疫疗法可能会对骨肌肉产生负面影响,导致癌症患者的肌肉消耗和功能衰退.
- 了解这些影响对于患者护理至关重要.
研究的目的:
- 审查癌症免疫疗法影响骨肌肉的机制.
- 讨论在免疫治疗期间评估肌肉完整性和功能的方法.
- 探索减轻免疫治疗引起的肌肉损伤的策略.
主要方法:
- 关于癌症免疫疗法和骨肌肉的现有文献的审查.
- 专注于与免疫相关的肌肉炎,炎症和瘤微环境 (TME) 改变.
- 讨论生物力学评估技术,如电阻肌图和超声波成像.
主要成果:
- 突出了免疫治疗在抑制瘤和肌肉损伤方面的双重作用.
- 关键因素包括炎症性细胞因子,免疫检查点和TME代谢障碍.
- 免疫相关的肌肉炎和炎症是导致肌肉衰竭的重要因素.
结论:
- 将免疫疗法与营养或抗炎干预相结合的组合疗法显示出减轻肌肉衰竭的前景.
- 需要进一步的研究来优化免疫疗法协议,以保持肌肉健康.
- 改善肌肉健康可以提高癌症治疗期间患者的治疗结果和生活质量.
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