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Updated: May 23, 2025

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部分线粒体参与PT-112的抗增殖和免疫刺激作用

Ruth Soler-Agesta1,2, Manuel Beltrán-Visiedo1,3, Ai Sato1,3

  • 1Department of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA.

Oncoimmunology
|May 19, 2025
PubMed
概括

新型癌症药物PT-112通过触发免疫细胞死亡 (ICD) 来抑制瘤细胞的生长. 它的有效性部分与线粒体外膜通透性 (MOMP) 相关,但即使在MOMP缺陷的细胞中,它仍然活跃.

关键词:
CD8+细胞毒性T淋巴细胞在CGAS中,CGAS是最重要的.在PD-1中使用PD-1.与损伤相关的分子模式.免疫检查点抑制剂 免疫检查点抑制剂我们的mtDNA mtDNA

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