从肝脏到四肢:探索脂肪肝病与外周动脉疾病之间的关联 - 一个系统性审查
Vera Ciornolutchii1, Abdulrahman Ismaiel1, Jennifer Bogdan2
12nd Department of Internal Medicine, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.
European journal of clinical investigation
|May 19, 2025
概括
脂肪肝疾病 (NAFLD/MAFLD) 与较高的外周动脉疾病 (PAD) 风险有关,特别是糖尿病或代谢综合征. 肝纤维化可能会加剧这种关联,需要进一步研究新的定义.
科学领域:
- 心脏病学 心脏病学
- 肝病学 肝病学是一种肝病学.
- 公共卫生 公共卫生
背景情况:
- 脂肪肝疾病 (NAFLD,MAFLD,MASLD) 是一个与心血管相关的全球健康问题.
- 周围动脉疾病 (PAD) 与脂肪肝疾病共享胰岛素抵抗和炎症等危险因素.
- 现有的研究表明,脂肪肝病与PAD之间存在联系,但需要进一步澄清.
研究的目的:
- 系统地审查和综合当前关于脂肪肝疾病和外围动脉疾病之间的关联的研究.
- 评估各种脂肪肝疾病定义与PAD风险之间的联系的强度和一致性.
主要方法:
- 在PubMed,Embase和Scopus进行了系统的文献搜索,截至2024年12月19日.
- 包含了11项涉及超过848,000名参与者的观察性研究,并使用纽卡斯尔-太华尺度对其质量进行了评估.
- 在NAFLD,MAFLD或MASLD患者中检查PAD的研究符合分析条件.
主要成果:
- 大多数研究发现NAFLD/MAFLD与PAD风险增加之间存在显著的关联,特别是在2型糖尿病和代谢综合征患者中.
- 与NAFLD定义相比,MAFLD标准显示PAD与PAD的相关性更强.
- 肝纤维化与较高的PAD风险有关,尽管并非所有研究都报告了一致的发现,也没有使用MASLD标准.
结论:
- 患有NAFLD/MAFLD的患者,特别是代谢并发症患者,可能面临PAD的风险增加.
- 肝病的严重程度,包括纤维化,似乎是导致PAD风险的一个因素.
- 未来的研究应该采用MASLD标准和先进的诊断来完善理解和指导综合护理策略.
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