在SARS-CoV-2感染后长期持续的头痛:一项基于人口的随访研究
Lénia Silva1, Joana Fernandes1, Rui Lopes1
1Neurology Department, Centro Hospitalar Universitário Do Porto, ULS Santo António, Porto, Portugal.
European journal of neurology
|May 19, 2025
概括
新发性持续性头痛,特别是偏头痛 (MLH),在COVID-19感染后两年很常见. 这项研究强调了COVID-19后 de novo MLH 的发病率增加.
科学领域:
- 神经学 神经学
- 传染性疾病 传染性疾病
- 流行病学 流行病学
背景情况:
- 头痛是长期COVID综合征的一个公认症状.
- 在COVID-19感染后新发作头痛的发生率和特征尚不清楚.
- 这项研究旨在在基于人口的COVID-19患者的潜在队列中对新发作头痛进行表征.
研究的目的:
- 在COVID-19感染后,在以前没有经历过头痛的个体中,描述新发作头痛的发生率和特征.
- 评估SARS-CoV-2感染后长期 (24个月) 患病率和持续性头痛的类型.
主要方法:
- 在2020年3月至6月期间诊断的732名COVID-19患者的前性队列研究.
- 在3,12和24个月通过面对面或电话咨询进行神经学后续检查.
- 结构化临床问卷以评估感染前和24个月后的头痛史.
主要成果:
- 448名患者完成了24个月的随访;平均年龄为51.6岁,60.7%为女性.
- 在以前没有头痛的患者中,新发性持续性头痛发生在16.2% (54/333) 的患者中.
- 这些患者中有64.8% (35/54) 符合偏头痛类头痛 (MLH) 标准,累计发病率为42/1000/年.
结论:
- 新发性持续性头痛在COVID-19后两年很常见,MLH是最常见的类型.
- 在COVID-19之后,MLH的发生率较高.
- 在COVID-19后新发MLH的个体往往比普通偏头痛患者年龄大,这对公众健康和生活质量有重大影响.
相关概念视频
01:29Coronavirus
Coronaviruses, including the severe acute respiratory syndrome coronavirus (SARS-CoV), are enveloped viruses characterized by their single-stranded, positive-sense RNA genome and helical nucleocapsid structure. The hallmark of these viruses is their club-shaped spike (S) glycoproteins that protrude from the viral envelope, facilitating attachment to host cells. Typically, coronaviruses infect the upper respiratory tract, often causing mild or asymptomatic disease. However, certain strains like...
01:26Encephalitis ll: Pathophysiology
Encephalitis is inflammation of the brain parenchyma caused by direct viral invasion or immune-mediated mechanisms triggered by infections or tumors. Both processes lead to neuronal injury, disrupted neurotransmission, and diverse neurological symptoms, often with overlapping clinical and pathological features.Autoimmune EncephalitisIn autoimmune encephalitis, antibodies target neuronal antigens on cell surfaces, synapses, or within neurons. A key example is anti-NMDAR encephalitis, which can...
01:26Brain Abscess l: Introduction
A brain abscess is a focal, intracerebral infection characterized by a localized collection of pus within the brain parenchyma, resulting from microbial invasion and the body’s inflammatory response. It progresses through stages: early and late cerebritis, followed by early and late capsule formation, reflecting tissue destruction, immune response, and eventual encapsulation.Etiology and PathogenesisCausative organisms vary with source and host factors, often involving polymicrobial infections,...
01:14Increased Intracranial Pressure l: Introduction
Intracranial hypertension is a sustained elevation of intracranial pressure (ICP) above 22 mm Hg. In supine adults, normal ICP is ~7–15 mm Hg.The rigid, nonexpandable cranium contains three components—brain tissue, blood, and cerebrospinal fluid (CSF)—that total ~1,700 mL in a typical adult: 1,400 mL brain (~80%), 150 mL blood (~10%), and 150 mL CSF (~10%). According to the Monro–Kellie doctrine, total intracranial volume is effectively fixed. When one component expands, CSF and venous blood...
01:29Increased Intracranial Pressure ll: Pathophysiology
Increased intracranial pressure (ICP) refers to a potentially life-threatening rise in pressure inside the skull. This usually happens when there is a major change in the volume of brain tissue, blood, or cerebrospinal fluid (CSF) — the three components inside the skull. According to the Monro-Kellie doctrine, if the volume of one component increases, the volumes of the other components must decrease to maintain normal pressure. If this does not happen, ICP rises.The process often begins with...