基于纵向神经成像和认知评估,描述轻度认知障碍和逆转后的双向转变
Yao Qin1,2,3, Jing Cui1, Durong Chen1
1Department of Health Statistics, School of Public Health, Shanxi Medical University, Taiyuan, Shanxi, China.
概括
轻度认知障碍 (MCI) 患者可以恢复正常认知 (NC),但面临持续认知恶化的风险. 那些从MCI恢复到NC的人仍然面临未来认知能力下降的更高风险.
科学领域:
- 神经科学是一个神经科学.
- 老年学是指老年学的学科.
- 生物统计学 生物统计学
背景情况:
- 描述认知状态的转变,特别是从轻度认知障碍 (MCI) 恢复到正常认知 (NC) 和随后的结果,至关重要但有限.
- 了解逆转后的认知稳定性和恶化模式对于临床管理至关重要.
研究的目的:
- 开发和应用一个功能多态模型 (FMSM) 来估计认知状态之间的纵向过渡概率.
- 描述从MCI回归到NC的模式以及随后的认知恶化的风险.
主要方法:
- 使用了MCI诊断的回顾性队列和至少两次后续访问 (2005-2022).
- 开发了一个功能多态模型框架来估计纵向过渡概率.
- 结合了使用fMLFPCA和MVFPCA的纵向神经成像和神经心理数据.
主要成果:
- 从MCI回归到NC的概率从基线时的2%增加到10年达到8%的峰值.
- 对于那些回到NC的人来说,到第10年回到MCI的概率从8%上升到35.71%,然后稳定下来.
- 患有MCI进展的风险与那些已经恢复的MCI复发的风险相似.
结论:
- 从MCI恢复到NC的个体仍然存在认知恶化风险较高.
- 开发的FMSM有效地使用多个纵向标记模型复杂的认知过渡.
- 这项研究强调了认知状态的动态性和考虑时空变化的重要性.
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