HPV42:一种常见的低风险HPV类型,与独特的宫阴道和皮肤新生病相关
Karen L Talia1, David Hawkes2,3,4, Gloria Zhang5
1Department of Pathology, Royal Children's and Royal Women's Hospital.
The American journal of surgical pathology
|May 19, 2025
概括
宫和阴道的斑块性角质炎样病变 (SKLL) 是一种罕见的,与低风险人乳头瘤病毒 (LRHPV) 类型42相关的独特病变. 这种病毒还导致罕见的侵袭性皮肤瘤,表明更广泛的致癌潜力.
科学领域:
- 妇科病理学 妇科病理学
- 皮肤病理学 皮肤病理学
- 病毒学 病毒学
背景情况:
- 斑块性角质炎样病变 (SKLL) 是一种罕见的宫和阴道病变,具有独特的形态,与其他状内皮病变不同.
- SKLL缺乏病毒细胞病变效应 (koilocytosis),但类似于皮肤斑块性角质炎.
研究的目的:
- 描述SKLL的形态,并调查其与人类乳头瘤病毒 (HPV) 的关联.
- 探索低风险HPV (LRHPV) 类型42的致癌潜力.
主要方法:
- 对17个SKLL病例进行了形态分析.
- 使用分子方法进行HPV类型识别.
- 与 papillary immature metaplasia 的病例进行比较.
- 关于HPV42相关瘤的文献综述.
主要成果:
- 在17例SKLL病例中的13例中检测到了HPV42;在3例中发现了其他LRHPV类型.
- 两个SKLL显示高度形态和p16阳性,表明HPV42.2的潜在瘤发生.
- 乳头不成熟转质症的病例是HPV42负的.
- HPV42与数字乳头腺癌 (DPA) 有关,这是一种罕见的侵袭性皮肤瘤.
结论:
- HPV42与SKLL和DPA有关,这表明这种LRHPV的罕见致癌潜力.
- 这些发现强调了多样化的HPV基因型-表型关联以及HPV类型在新瘤中的重要性.
更多相关视频
10:26RNAscope for In situ Detection of Transcriptionally Active Human Papillomavirus in Head and Neck Squamous Cell Carcinoma
Published on: March 11, 2014
27.2K
07:43Four-color Fluorescence Immunohistochemistry of T-cell Subpopulations in Archival Formalin-fixed, Paraffin-embedded Human Oropharyngeal Squamous Cell Carcinoma Samples
Published on: July 29, 2017
9.6K
相关概念视频
Rous Sarcoma Virus (RSV) and Cancer
4.9K
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
4.9K
Skin Cancer
3.0K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
3.0K
Cancer Vaccines
321
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
321
Mechanisms of Retrovirus-induced Cancers
5.0K
Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...
5.0K
Cancer Prevention
6.0K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
6.0K
Disorders of the Female Reproductive System
290
The female reproductive system can be affected by several disorders, including Premenstrual Syndrome (PMS), Premenstrual Dysphoric Disorder (PMDD), endometriosis, and various forms of cancer. PMS and PMDD are cyclical conditions that cause physical and emotional distress, with symptoms that include edema, mood swings, and food cravings. PMDD is a more severe form of PMS characterized by increased symptom severity that peaks during the luteal phase and tends to improve or resolve shortly after...
290
