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低剂量口服牛奶挑战对完全避免患者的结果:日本的一项多中心研究

Yuki Sakaguchi¹, Ken-Ichi Nagakura¹, Kyohei Takahashi¹

¹Department of Allergy, Clinical Research Center for Allergy and Rheumatology, NHO Sagamihara National Hospital, Sagamihara, Kanagawa, Japan.

Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology

|May 19, 2025

概括

高牛奶 (CM) 特定免疫球蛋白E (sIgE) 和素sIgE水平是积极的低剂量CM口服食品挑战 (OFC) 和过敏反应风险的关键预测指标. 这些生物标志物有助于评估儿科过敏评估的结果.

科学领域:

过敏和免疫学过敏和免疫学
儿科胃肠病学儿科胃肠病学
食物过敏研究食物过敏研究

背景情况:

关于在低剂量牛奶 (CM) 口服食品挑战 (OFC) 期间发生过敏反应的危险因素的数据有限.
调查这些因素对于管理儿科食物过敏至关重要.
需要多中心研究来确定高风险的OFC.

研究的目的:

为了确定积极的低剂量CM OFCs的显著风险因素.
为了确定CM OFCs期间过敏反应的预测因素.
为预测CM OFC结果建立最佳生物标志物值.

主要方法:

来自10家日本医院的低剂量CM OFCs的回顾性分析 (2019年).
包括在OFC之前完全消除CM的患者.
后勤回归和接收器运行特征 (ROC) 曲线分析以确定风险因素和最佳截止值.

主要成果:

包括244名患者;44%的患者呈阳性CM OFC,19%的患者出现过敏反应.
较高的CM特异性免疫球蛋白E (sIgE) 和素sIgE水平是OFC阳性的显著预测因素 (p < .001).
对CM和素sIgE的最佳截止值分别为5.4和7.3kU_A/L. ≥100kU_A/L的水平与20%的过敏反应概率相关.

结论:

牛奶 (CM) 和素特异性免疫球蛋白E (sIgE) 水平对于预测低剂量CM口服食品挑战 (OFC) 的结果非常有价值.
这些生物标志物有助于对接受CM OFCs的儿科患者的风险分层.
进一步的研究可以完善食品过敏管理的预测模型.

关键词:

过敏反应是一种过敏反应.咖啡因中的咖啡因.牛奶是一种牛奶.食物过敏食物过敏低剂量的低剂量口服食物挑战口服食物挑战风险因素的风险因素是什么

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