概括
这项研究在健康的东中国成年人中确定了尿蛋白标记物的特定年龄和性别的参考间隔. 这些新的参考间隔对于精确查和监测病至关重要.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 临床化学 临床化学
- 生物标志物发现发现
背景情况:
- 微专和蛋白质等尿路标记物对于慢性病 (CKD) 的评估至关重要.
- 在中国东部,这些标志物的确定的参考区间 (RIs) 缺乏.
- 这项研究解决了对尿蛋白标记物的局部RI的需求.
研究的目的:
- 调查和建立尿蛋白标记物的特定年龄和性别的参考间隔 (RIs).
- 为中国东部脏疾病查和管理提供关键资源.
主要方法:
- 分析了中国东部6786名健康个体 (2022-2023) 的数据.
- 采用了Box-Cox转换和Tukey的数据规范化和异常值去除方法.
- 使用非参数方法来估计RI,将上限设置为95百分位数.
主要成果:
- 在尿路蛋白标记物中观察到基于性别的显著差异,除了视网醇结合蛋白 (RBP).
- 免疫球蛋白G (IgG),α1-微球蛋白 (α1-MG),转激素 (TRF) 和N-乙-β-D-葡萄糖酶 (NAG) 的水平,以及它们的肌素比率,随着年龄的增长而增加.
- 对于大多数标记物,除了男性的RBP,微专蛋白 (mALB) 和α1-MG外,观察到与年龄相关的差异.
结论:
- 在健康的东中国人群中,为六种尿蛋白标记物及其肌素比率建立了年龄和性别特定的RI.
- 这些RI对于改善病查,治疗和监测具有重要意义.
- 强调在解释尿蛋白标志物水平时考虑年龄和性别的重要性.
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