S100A12 青少年异常性关节炎 (JIA) 中的蛋白质水平:系统性审查和元分析
Clinical laboratory
|May 19, 2025
概括
血清S100A12蛋白水平在患有青少年异常性关节炎 (JIA) 的儿童中相比于健康个体显著升高. 这一发现表明S100A12可能作为诊断JIA的潜在生物标志物.
科学领域:
- 生物化学 生物化学
- 免疫学 免疫学 免疫学
- 儿科 儿科 儿科
背景情况:
- 青少年异常性关节炎 (JIA) 是儿童残疾的一个重要原因.
- 以前的研究表明,S100A12蛋白水平与JIA之间存在不一致的关联.
- 需要进一步调查,以澄清S100A12在JIA中的作用.
研究的目的:
- 系统地审查和元分析S100A12蛋白水平与JIA之间的关联.
- 评估S100A12作为JIA生物标志物的诊断潜力.
主要方法:
- 在Embase,PubMed/Medline,Web of Science和Scopus的系统文献搜索,截至2022年12月.
- 包括9项研究,518名JIA患者和345名健康对照.
- 使用R-4.4.0软件进行数据分析.
主要成果:
- 聚合分析显示,与健康对照组相比,JIA患者的血清S100A12蛋白水平显著更高 (SMD=2.18).
- 根据地理位置 (欧洲,亚洲) 和研究类型 (队列,病例控制) 的子组分析也显示了S100A12水平的显著增加.
- 在各个子组中观察到很高的异质性,表明研究结果的变化.
结论:
- 在JIA患者中,血清S100A12蛋白度显著升高.
- 蛋白质S100A12显示出作为青少年形性关节炎生物标志物的潜力.
- 进一步的研究可能会完善S100A12在JIA诊断和管理中的临床实用性.
相关概念视频
01:20The JAK-STAT Signaling Pathway
8.7K
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...
8.7K
01:11Genome-wide Association Studies-GWAS
13.2K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
13.2K